Three‐Step Total Synthesis of Ramelteon via a Catellani Strategy
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901355
Abstract: Ramelteon is the first medicine in human history that treat insomnia as a melatonin receptor agonist. Herein, we report an efficient three‐step synthetic route to access it from commercially available 2,3‐dihydrobenzofuran‐4‐amine, which represents as the… read more here.
Keywords: three step; catellani; ramelteon; step total ... See more keywords
Five-Step Total Synthesis of (±)-Aspidospermidine by a Lactam Strategy via an Azomethine Ylide.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00735
Abstract: A five-step total synthesis of (±)-aspidospermidine (1) based on a lactam strategy is reported. Our synthesis features an iridium-catalyzed reductive Michael addition/[3+2] cycloaddition cascade to give a tricyclic ketone intermediate from a simple lactam via… read more here.
Keywords: five step; step total; total synthesis; strategy ... See more keywords
Six-Step Total Synthesis of Isohirsut-4-ene through [5+2+1] Cycloaddition and Transannular Epoxide-Alkene Cyclization.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04383
Abstract: A six-step total synthesis of isohirsut-4-ene with a 5/5/5 tricyclic core has been achieved. The synthesis features a Rh(I)-catalyzed [5+2+1] cycloaddition, a Corey-Chaykovsky reaction, and a transannular epoxide-alkene cyclization that afford the skeleton of the… read more here.
Keywords: step; synthesis; synthesis isohirsut; six step ... See more keywords
Enantioselective Organocatalytic Conjugate Addition in a Tandem Synthesis of δ-Substituted Cyclohexenones and Four-Step Total Synthesis of Penienone.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01976
Abstract: A bisperfluorotoluyl-BINOL catalyzed conjugate addition of trifluoroborate salts to doubly vinylogous esters and aldol condensation synthesized chiral δ-substituted cyclohexenones with high yields and enantioselectivities (10 examples, up to 89% yield, 89-98% ee). Stepwise and single-pot… read more here.
Keywords: conjugate addition; synthesis; four step; substituted cyclohexenones ... See more keywords
Four-Step Total Synthesis of (+)-Yaoshanenolides A and B
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b00701
Abstract: A highly concise bioinspired four-step total synthesis of yaoshanenolides A and B possessing tricyclic spirolactone with an unusual 5′H-spiro-[bicyclo[2.2.2]-oct[2]ene-7,2′-furan]-5′-one scaffold is reported. This synthesis features high-yielding aldol-type addition of γ-butyrolactone on to the aldehyde, exocyclic… read more here.
Keywords: synthesis yaoshanenolides; step total; four step; total synthesis ... See more keywords
13-Step Total Synthesis of Atropurpuran.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b00391
Abstract: Herein, we report a concise total synthesis of atropurpuran, a unique and synthetically challenging pentacyclic diterpene that bears a tetracyclo[5.3.3.04,9.04,12]-tridecane skeleton that is unprecedented among natural terpenes. This 13-step approach features a strategy that include… read more here.
Keywords: total synthesis; step total; synthesis; synthesis atropurpuran ... See more keywords
A bioinspired, one-step total synthesis of peshawaraquinone
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc05377b
Abstract: A concise synthesis of a stereochemically complex meroterpenoid, peshawaraquinone, via the unsymmetrical dimerization of its achiral precursor, dehydro-α-lapachone, is reported. Enabled by reversible oxa-6π-electrocyclizations of 2H-pyran intermediates, the base-catalyzed dimerization sets up an intramolecular (3… read more here.
Keywords: synthesis peshawaraquinone; peshawaraquinone; one step; synthesis ... See more keywords
Step-by-step total pelviperitonectomy with modified posterior pelvic exenteration
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Gynecological Cancer"
DOI: 10.1136/ijgc-2019-000984
Abstract: The fundamental aim of advanced ovarian cancer surgery is to obtain complete cytoreduction. Due to the pelvic anatomy, en bloc removal of the uterus, adnexa, rectum, and surrounding peritoneum is mandatory.[1][1] The effect of complete… read more here.
Keywords: step step; step total; step; modified posterior ... See more keywords