Early Steps of the Biosynthesis of the Anticancer Antibiotic Pleurotin
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DOI: 10.1021/acschembio.4c00599
Abstract: Pleurotin is a meroterpenoid specialised metabolite made by the fungus Hohenbuehelia grisea, and it is a lead anticancer molecule due to its irreversible inhibition of the thioredoxin-thioredoxin reductase system. Total synthesis of pleurotin has previously… read more here.
Keywords: early steps; anticancer antibiotic; biosynthesis anticancer; steps biosynthesis ... See more keywords
Oxidative steps during the biosynthesis of squalestatin S1††Electronic supplementary information (ESI) available: All experimental procedures and analytical data. See DOI: 10.1039/c8sc02615g
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc02615g
Abstract: Two enzymes of previously unknown function encoded by the squalestatin biosynthetic gene cluster from the fungus Phoma MF5453 catalyse a remarkable series of six consecutive oxidations to form the 4,8-dioxa-bicyclo[3.2.1]octane core of the squalestatins. read more here.
Keywords: steps biosynthesis; oxidative steps; supplementary information; squalestatin electronic ... See more keywords