A detailed characterization of stepwise activation of the androgen receptor variant 7 in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01585-5
Abstract: Expression of the androgen receptor splice variant 7 (AR-V7) is frequently detected in castrate resistant prostate cancer and associated with resistance to AR-targeted therapies. While we have previously noted that homodimerization is required for the… read more here.
Keywords: stepwise activation; prostate cancer; cancer cells; cancer ... See more keywords
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.44364
Abstract: Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca2+-dependent lipid scramblase, its regulation mechanism has remained… read more here.
Keywords: stepwise activation; scramblase; activation mechanism; mechanism ... See more keywords