Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays.
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DOI: 10.1016/j.jviromet.2017.05.013
Abstract: Twenty amino acid substitutions in the thymidine kinase (TK) of clinical herpes simplex virus type 1 strains were assessed for conferring acyclovir (ACV) resistance. Site-directed mutagenesis, cell-free protein synthesis and protein expression in Escherichia coli… read more here.
Keywords: stepwise characterization; activity towards; characterization non; activity ... See more keywords