Absolute Configurations and Stereochemical Inversion Mechanism of Epimeric Securinega Alkaloids from Flueggea suffruticosa.
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DOI: 10.1021/acs.orglett.0c01167
Abstract: Three pairs of Securinega alkaloid epimers with a piperidin-2-yl moiety (1-6) were isolated from Flueggea suffruticosa, and their structures including absolute configurations were definitely characterized. An interconvertible C-2' epimerization process within each pair of epimers… read more here.
Keywords: flueggea suffruticosa; inversion mechanism; absolute configurations; stereochemical inversion ... See more keywords
Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon
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DOI: 10.1038/s42004-018-0100-5
Abstract: Peptides and small proteins are attractive therapeutic candidates due to their inherent selectivity and limited off-target effects. Unfortunately, their potential is often hindered by unfavorable physicochemical properties. This is particularly true in the case of… read more here.
Keywords: glucagon; aqueous solubility; therapeutic peptides; stereochemical inversion ... See more keywords
CO2-Driven stereochemical inversion of sugars to create thymidine-based polycarbonates by ring-opening polymerisation
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DOI: 10.1039/c7py00118e
Abstract: The development of biodegradable polymers from renewable resources is vital in addressing the dependence of plastics on petroleum-based feedstocks and growing ocean and landfill waste. Herein, both CO2 and natural sugar diols are utilised as… read more here.
Keywords: ring opening; opening polymerisation; thymidine based; stereochemical inversion ... See more keywords