Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe.
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DOI: 10.1021/jacs.7b06019
Abstract: The possibility of a double Walden inversion mechanism of the fluoracetate dehalogenase FAcD (RPA1163) has been studied by subjecting rac-2-fluoro-2-phenyl acetic acid to the defluorination process. This stereochemical probe led to inversion of configuration in… read more here.
Keywords: substrate scope; stereochemical probe; scope enantioselectivity; investigating substrate ... See more keywords