Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin.
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DOI: 10.1021/acsmedchemlett.8b00050
Abstract: Tetrahydrolipstatin (THL), its enantiomer, and an additional six diastereomers were evaluated as inhibitors of the hydrolysis of p-nitrophenyl butyrate by porcine pancreatic lipase. IC50s were found for all eight stereoisomers ranging from a low of… read more here.
Keywords: relationship studies; stereochemical structure; sar tetrahydrolipstatin; activity relationship ... See more keywords