Advances and challenges in the pharmacokinetics and bioanalysis of chiral drugs.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23495
Abstract: Enantioselective analytical approaches are essential for monitoring pharmacokinetics and acquiring accurate data to better understand the role of stereochemistry in pharmacokinetics. Enantioselectivity significantly impacts the pharmacokinetics of chiral drugs, especially in metabolic profile, leading to… read more here.
Keywords: challenges pharmacokinetics; pharmacokinetics bioanalysis; bioanalysis chiral; advances challenges ... See more keywords
Stereochemistry-activity relationship of ceramide-induced exosome production to clear amyloid-β in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23568
Abstract: Stereochemistry has a substantial impact on the biological activity of various drugs. We investigated the role of stereochemistry of ceramides in inducing the production of exosomes, a type of extracellular vesicle, from neuronal cells, with… read more here.
Keywords: alzheimer disease; stereochemistry; activity; exosome production ... See more keywords
Stereochemistry, Stereodynamics, and Redox and Complexation Behaviors of 2,2'-Diaryl-1,1'-Biazulenes.
Sign Up to like & getrecommendations! Published in 2019 at "ChemPlusChem"
DOI: 10.1002/cplu.201900262
Abstract: 2,2'-Diaryl-1,1'-biazulenes were synthesized and electronic communication between the azulene subunits was suggested based on redox measurements. The linkage of azulene at the 1-position also appeared to increase the HOMO levels. In addition, cyclic voltammetry measurements… read more here.
Keywords: diaryl biazulenes; stereochemistry stereodynamics; stereodynamics redox; redox complexation ... See more keywords
Core packing of well‐defined X‐ray and NMR structures is the same
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4373
Abstract: Numerous studies have investigated the differences and similarities between protein structures determined by solution NMR spectroscopy and those determined by X‐ray crystallography. A fundamental question is whether any observed differences are due to differing methodologies… read more here.
Keywords: nmr structures; ray; structures determined; stereochemistry ... See more keywords
Preparation of menisdaurigenin and related compounds
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-018-1235-5
Abstract: Menisdaurin (1), a cyano glucoside, was first isolated in 1978 from Menispermum dauricum (Menispermaceae) and named after the plant. It has been also isolated from several plant sources. The stereochemistry of the aglycone part was… read more here.
Keywords: stereochemistry; menisdaurigenin related; preparation menisdaurigenin; hydrolysis ... See more keywords
Establishing the structure-activity relationship of teixobactin
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.07.004
Abstract: Abstract In 2015, a new antimicrobial peptide agent was discovered, termed teixobactin. Over the past few years, the structure-activity relationship of teixobactin has been extensively studied. Here, the updated studies have been summarized to provide… read more here.
Keywords: teixobactin; activity; stereochemistry; structure activity ... See more keywords
Synthesis and stereochemistry assignment of (3R,5R)- and (3S,5R)-4-benzyl-3-(3,4-dimethoxyphenyl)-5-phenyl-1,4-oxazin-2-ones
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.05.091
Abstract: Abstract The diastereoselective synthesis of 3,5-disubstituted 1,4-oxazin-2-ones, the valuable intermediates on the route to tetrahydroisoquinoline derivatives, was based on the Petasis reaction in which (R)-(−)-N-benzyl-2-phenylglycinol was used as the amine component. It was demonstrated that… read more here.
Keywords: synthesis stereochemistry; oxazin ones; benzyl; stereochemistry assignment ... See more keywords
Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2017.10.004
Abstract: Nepetalactones are iridoid monoterpenes with a broad range of biological activities produced by plants in the Nepeta genus. However, none of the genes for nepetalactone biosynthesis have been discovered. Here we report the transcriptomes of… read more here.
Keywords: species iridoid; nepeta species; stereochemistry; iridoid synthase ... See more keywords
ns2np4 (n = 4, 5) lone pair triplets whirling in M*F2E3 (M* = Kr, Xe): Stereochemistry and ab initio analyses
Sign Up to like & getrecommendations! Published in 2017 at "Solid State Sciences"
DOI: 10.1016/j.solidstatesciences.2016.12.004
Abstract: Abstract The stereochemistry of n s 2 n p 4 ( n = 4, 5) lone pair LP characterizing noble gas Kr and Xe (labeled M*) in M*F 2 difluorides is examined within coherent crystal chemistry… read more here.
Keywords: lone pair; triplets whirling; stereochemistry; pair triplets ... See more keywords
Stereochemistry of internucleoside phosphorus atom affects sugar pucker and acid hydrolysis of N3′-P5′ thio-phosphoramidates
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2021.152834
Abstract: Abstract Investigation of the sugar pucker of the two diastereomers of dinucleotide N3′-P5′-thio-phosphoramidates TNPSTNH2 and TNPSTOH shows that the Sp isomer adopts a more C3′-endo (North) sugar ring configuration than the Rp counterpart. In contrast,… read more here.
Keywords: sugar pucker; acid hydrolysis; thio phosphoramidates; stereochemistry ... See more keywords
Click Step-Growth Polymerization and E/Z Stereochemistry Using Nucleophilic Thiol–yne/–ene Reactions: Applying Old Concepts for Practical Sustainable (Bio)Materials
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of Chemical Research"
DOI: 10.1021/acs.accounts.2c00293
Abstract: Conspectus Polymer sustainability is synonymous with “bioderived polymers” and the zeitgeist of “using renewable feedstocks”. However, this sentiment does not adequately encompass the requirements of sustainability in polymers. In addition to recycling considerations and mechanical… read more here.
Keywords: step growth; stereochemistry; thiol yne; chemistry ... See more keywords