Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide
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DOI: 10.1126/sciadv.aao6718
Abstract: Metallosupramolecular complexes can enantioselectively target the central hydrophobic α/β discordant stretch of Aβ. Stereochemistry is vital for pharmaceutical development and can determine drug efficacy. Herein, 10 pairs of asymmetric triplex metallohelix enantiomers as a library… read more here.
Keywords: asymmetric triplex; amyloid inhibition; triplex metallohelices; inhibition ... See more keywords