Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds.
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DOI: 10.1021/jacs.8b07319
Abstract: Target- and phenotype-agnostic assessments of biological activity have emerged as viable strategies for prioritizing scaffolds, structural features, and synthetic pathways in screening sets, with the goal of increasing performance diversity. Here, we describe the synthesis… read more here.
Keywords: performance diversity; biological activity; stereochemistry appendages;