Synthesis and stereochemistry assignment of (3R,5R)- and (3S,5R)-4-benzyl-3-(3,4-dimethoxyphenyl)-5-phenyl-1,4-oxazin-2-ones
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DOI: 10.1016/j.molstruc.2019.05.091
Abstract: Abstract The diastereoselective synthesis of 3,5-disubstituted 1,4-oxazin-2-ones, the valuable intermediates on the route to tetrahydroisoquinoline derivatives, was based on the Petasis reaction in which (R)-(−)-N-benzyl-2-phenylglycinol was used as the amine component. It was demonstrated that… read more here.
Keywords: synthesis stereochemistry; oxazin ones; benzyl; stereochemistry assignment ... See more keywords