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Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad268
Abstract: Abstract Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-acetylgalactosamine (GalNAc)-conjugated siRNAs…
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Keywords:
potency durability;
stereopure;
impact stereopure;
rna interference ... See more keywords
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1
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103265
Abstract: The chiral drug candidates have more effective binding affinities for their specific protein or receptor site for the onset of pharmacological action. Achieving all carbon stereopure compounds is not trivial in chemical synthesis. However, with…
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Keywords:
hydroxy trifluoromethyl;
antidiabetic agent;
synthesis;
stereopure ... See more keywords