Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03131
Abstract: Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of… read more here.
Keywords: amino acids; azetidine based; stereoselective access; small peptide ... See more keywords
Cyclocarbopalladation/Stille Cascade: Stereoselective Access to Quaternary Functionalized Carbons.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02400
Abstract: Exploration of the 4-exo-dig cyclocarbopalladation in the discovery of new and original scaffolds afforded some unexpected results. The search for a way to produce seven-membered ring systems led to polycyclic molecules bearing a tetrasubstituted carbon.… read more here.
Keywords: cyclocarbopalladation stille; stille cascade; access quaternary; stereoselective access ... See more keywords
Stereoselective access to 2-deoxy-2-trifluoromethyl sugar mimetics by trifluoromethyl-directed 1,2-trans glycosylation
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00274h
Abstract: A general methodology featuring a trifluoromethyl-directed 1,2-trans glycosylation reaction as a key step has been developed to give access to various 2-CF3-glycoconjugates, including carbohydrate epitopes, amino acids, and lipids. read more here.
Keywords: directed trans; trifluoromethyl directed; trans glycosylation; stereoselective access ... See more keywords
Aziridine Ring Opening as Regio- and Stereoselective Access to C-Glycosyl-Aminoethyl Sulfide Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061764
Abstract: A short synthetic route to stereoselective access to C-glycosyl-aminoethyl sulfide derivatives has been developed through the reaction of tributhyltin derivatives of glycals with aziridinecarboaldehyde and the regioselective ring opening of a chiral aziridine with thiophenol.… read more here.
Keywords: glycosyl aminoethyl; ring opening; access glycosyl; sulfide derivatives ... See more keywords