Metal-free stereoselective annulation of quinolines with trifluoroacetylacetylenes and water: an access to fluorinated oxazinoquinolines.
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DOI: 10.1039/c7cc09725e
Abstract: Metal-free reaction between quinolines, aryltrifluoroacetylacetylenes and water at -18 °C-rt in MeCN resulted in stereoselective assembly of trifluoromethylated oxazinoquinolines with up to 99% yield that was essentially in contrast to a similar reaction with pyridines.… read more here.
Keywords: quinolines trifluoroacetylacetylenes; water; free stereoselective; stereoselective annulation ... See more keywords
Iridium-catalyzed stereoselective [3+2] annulation of α-oxocarboxylic acids with 1,3-dienes.
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DOI: 10.1039/d1cc02003j
Abstract: The stereoselective annulation of α-oxocarboxylic acids with 1,3-dienes proceeded in the presence of a hydroxoiridium catalyst to give α-hydroxy-γ-lactones in good yields with high 3,5-trans relative stereochemistry. The use of a chiral diene ligand for… read more here.
Keywords: annulation; annulation oxocarboxylic; acids dienes; iridium catalyzed ... See more keywords
Organocatalyst Design for the Stereoselective Annulation towards Bicyclic Diketones and Analogues
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DOI: 10.3390/sym14020355
Abstract: The Wieland–Miescher ketone, Hajos–Parrish–Eder–Sauer–Wiechert ketone, and their analogues are bicyclic diketones essential as building blocks for the synthesis of several natural and bioactive molecules. For this reason, since 1971, when Hajos and Parrish and Eder,… read more here.
Keywords: organocatalyst design; towards bicyclic; bicyclic diketones; stereoselective annulation ... See more keywords