Palladium-Catalyzed Stereoselective Defluorosilylation of gem-Difluoroalkenes for the Synthesis of Tetrasubstituted Monofluorinated Vinylsilanes.
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DOI: 10.1021/acs.orglett.3c00718
Abstract: Stereoselective synthesis of tetrasubstituted vinylsilanes is a challenging task. We herein report a novel palladium(0)-catalyzed defluorosilylation of β,β-difluoroacrylates to access tetrasubstituted vinylsilanes containing the monofluoroalkene motif in excellent diastereoselectivities (>99:1). This is our first example… read more here.
Keywords: stereoselective defluorosilylation; palladium catalyzed; catalyzed stereoselective; synthesis tetrasubstituted ... See more keywords