Regio- and Stereoselective Palladium-Catalyzed C(sp3)-H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups.
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DOI: 10.1021/acs.orglett.8b01521
Abstract: The selective synthesis of cis-3,4-disubstituted pyrrolidines and piperidines is achieved by a Pd-catalyzed C-H arylation with excellent regio- and stereoselectivity using an aminoquinoline auxiliary at C(3). The arylation conditions are silver free, use a low… read more here.
Keywords: pyrrolidines piperidines; catalyzed sp3; stereoselective palladium; arylation ... See more keywords