Stereoselective Syntheses of Masked β-Amino Acid Containing Phthalides
Sign Up to like & getrecommendations! Published in 2022 at "Helvetica chimica acta"
DOI: 10.1002/hlca.202200110
Abstract: We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto’s bifunctional organocatalyst. This approach allows for the synthesis of various novel β2,2-amino acid-phthalide conjugates with good enantio-… read more here.
Keywords: acid containing; masked amino; syntheses masked; acid ... See more keywords
Stereoselective Syntheses of all the Possible Stereoisomers of Coronafacic Acid
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DOI: 10.1002/open.202000210
Abstract: Abstract An efficient and stereoselective syntheses of all the possible stereoisomers of coronafacic acid (CFA) has been developed. The stereochemistries of C3a and C7a were controlled in a diastereoselective Diels‐Alder type cycloaddition using a chiral… read more here.
Keywords: stereoisomers coronafacic; coronafacic acid; possible stereoisomers; syntheses possible ... See more keywords
Stereoselective Syntheses of ( E)-γ',δ-Bisboryl-Substituted syn-Homoallylic Alcohols via Chemoselective Aldehyde Allylboration.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00461
Abstract: The development of a novel ( Z)-α,δ-bisboryl-substituted crotylboron reagent is reported. Ni-catalyzed 1,4-diboration of dienylboronate provided the targeted crotylboronate in good yield with high regio- and stereoselectivity. Chemo- and stereoselective addition of this crotylboron reagent… read more here.
Keywords: syntheses bisboryl; substituted syn; syn homoallylic; bisboryl substituted ... See more keywords
Stereoselective Syntheses of 3′-Hydroxyamino- and 3′-Methoxyamino-2′,3′-Dideoxynucleosides
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DOI: 10.1021/acs.orglett.9b03474
Abstract: Aminonucleosides are used as key motifs in medicinal and bioconjugate chemistry; however, existing strategies toward 3′-hypernucleophilic amine systems do not readily deliver deoxyribo-configured products. We report diastereoselective syntheses of deoxyribo- and deoxyxylo-configured 3′-hydroxyamino- and 3′-methoxyamino-nucelosides… read more here.
Keywords: methoxyamino dideoxynucleosides; hydroxyamino methoxyamino; chemistry; stereoselective syntheses ... See more keywords
Catalytic enantioselective alkenylation–heteroarylation of olefins: stereoselective syntheses of 5–7 membered azacycles and oxacycles
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Science"
DOI: 10.1039/d2sc07117g
Abstract: Catalytic enantioselective domino alkenylation–heteroarylation of nonconjugated iododienes proceeded with excellent stereoselectivity and broad scope of substrates. The reaction enables stereoselective syntheses of substituted azacycles such as piperidine, pyrrolidine azepine and dihydropyrans carrying new quaternary stereocenters.… read more here.
Keywords: alkenylation heteroarylation; catalytic enantioselective; stereoselective syntheses; enantioselective alkenylation ... See more keywords