A new dipeptide as a selective gelator of Cu(ii), Zn(ii), and Pb(ii)
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DOI: 10.1039/d0ce01199a
Abstract: The various aspects associated with the incorporation of steric constraints into a series of dipeptides have been studied. The self-assembly propensities of the dipeptides carried out with the use of complementary experimental methods enabled us… read more here.
Keywords: peptide; steric constraints; selective gelator; dipeptide selective ... See more keywords
Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment
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DOI: 10.3390/ijms23137291
Abstract: Controlled inhibition of drug-metabolizing cytochrome P450 3A4 (CYP3A4) is utilized to boost bioavailability of anti-viral and immunosuppressant pharmaceuticals. We investigate structure–activity relationships (SARs) in analogues of ritonavir, a potent CYP3A4 inhibitor marketed as pharmacoenhancer, to… read more here.
Keywords: heme ligating; constraints imposed; pyridine attachment; steric constraints ... See more keywords