Highly Active Catalyst for Suzuki-Miyaura Coupling to Form Sterically Demanding Biaryls: Electronic Control of Pd through the Secondary Interaction Using a Buchwald-Type Ligand Bearing a Fluorinated Aryl Ring.
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DOI: 10.1021/acs.orglett.5c01467
Abstract: To accelerate reductive elimination in Suzuki-Miyaura coupling (SMC) through secondary interactions with a Buchwald-type ligand, a heptafluorotolyl group was introduced into the ligand's structure, guided by DFT calculations. The resulting ligand, HFTPhos, was effective for… read more here.
Keywords: type ligand; suzuki miyaura; ligand; buchwald type ... See more keywords
Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors
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DOI: 10.1021/acscatal.9b04617
Abstract: The biocatalytic Friedel–Crafts acylation has been identified recently for the acetylation of resorcinol using activated acetic acid esters for the synthesis of acetophenone derivatives catalyzed by an acyltransferase. Because the wild-type enzyme is limited to… read more here.
Keywords: engineered acyltransferase; transforms sterically; rational engineered; acyltransferase transforms ... See more keywords
Formation of silaimines from a sterically demanding iminophosphonamido chlorosilylene via intramolecular N-P bond cleavage.
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DOI: 10.1039/d1cc02812j
Abstract: The sterically demanding iminophosphonamido chlorosilylene [Ph2P(DipN)2]SiCl (Dip = 2,6-diisopropylphenyl) was synthesized and fully characterized using NMR spectroscopy and X-ray crystallography. Substitution reactions of [Ph2P(DipN)2]SiCl with N- and Fe-nucleophiles led to the unexpected formation of the… read more here.
Keywords: intramolecular bond; sterically demanding; via intramolecular; demanding iminophosphonamido ... See more keywords
A synthetic tactic to substitute axial ligands in sterically demanding Ru(II)porphyrinates.
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DOI: 10.1039/d2dt01095j
Abstract: We report a synthetic strategy that allows for the preparation of sterically encumbered heteroleptic Ru(II)porphyrinates with the desired configuration of stable/inert and weak/labile axial ligands to direct reactions between substrates to exclusively occur at the… read more here.
Keywords: tactic substitute; substitute axial; axial ligands; sterically demanding ... See more keywords
C–C Coupling in sterically demanding porphyrin environments
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DOI: 10.3762/bjoc.20.234
Abstract: Unlike their planar counterparts, classic synthetic protocols for C–C bond forming reactions on nonplanar porphyrins are underdeveloped. The development of C–C bond forming reactions on nonplanar porphyrins is critical in advancing this field of study… read more here.
Keywords: chemistry; porphyrin; coupling sterically; demanding porphyrin ... See more keywords