Pressure‐dependent fouling behavior during sterile filtration of mRNA‐containing lipid nanoparticles
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28200
Abstract: The COVID‐19 pandemic has generated growing interest in the development of mRNA‐based vaccines and therapeutics. However, the size and properties of the lipid nanoparticles (LNPs) used to deliver the nucleic acids can lead to unique… read more here.
Keywords: sterile filtration; filtration mrna; pressure; lipid nanoparticles ... See more keywords
Sterile filtration of a multi‐serotype glycoconjugate vaccine drug product
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DOI: 10.1002/bit.28342
Abstract: Glycoconjugate vaccines consisting of multiple serotypes of the bacterial capsular polysaccharide can provide strong protection against infection by significant pathogens. Previous studies of the sterile filtration behavior of these glycoconjugates have been limited to experiments… read more here.
Keywords: sterile filtration; drug; drug product; glycoconjugate ... See more keywords
Prefiltration enhances performance of sterile filtration for glycoconjugate vaccines
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DOI: 10.1002/btpr.3180
Abstract: Recent studies have reported very low capacity during sterile filtration of glycoconjugate vaccines due to rapid fouling of the sterile filter. The objective of this study was to explore the potential for significantly increasing the… read more here.
Keywords: sterile filter; filtration; size; glycoconjugate vaccines ... See more keywords
Comparative Evaluation of the Performance of Sterile Filters for Bioburden Protection and Final Fill in Biopharmaceutical Processes
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DOI: 10.3390/membranes12050524
Abstract: Sterile filtration processes are widely used in the production of biotherapeutics for microorganism removal and product sterility. Sterile filtration processes can be applied to buffer preparation and cell culture media preparation in biotherapeutics processes, and… read more here.
Keywords: sterile filters; sterile filtration; comparative evaluation; performance ... See more keywords