Conversion of carbonyl steroid derivatives to 1,1-dibromoalkenes by the catalytic olefination reaction and synthesis of functionally substituted steroids on their basis
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DOI: 10.1007/s11172-018-2106-7
Abstract: Catalytic olefination of carbonyl steroid derivatives were used to obtain the corresponding 1,1-dibromoalkenes. For this, N-unsubstituted steroid hydrazones were involved into the reaction with tetrabromomethane in the presence of copper(i) chloride. The dibromides can be… read more here.
Keywords: steroid derivatives; carbonyl steroid; reaction; catalytic olefination ... See more keywords
First report of steroid derivatives isolated from starfish Acanthaster planci with anti-bacterial, anti-cancer and anti-diabetic activities.
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DOI: 10.1080/14786419.2021.2021200
Abstract: Chemical studies on Acanthaster planci have afforded two steroids, 5α-cholesta-24-en-3β,20β-diol-23-one (1) and 5α-cholesta-9(11)-en-3β, 20β-diol (2). Structures compounds 1 and 2 were determined with the help of spectroscopic studies. Compound 1 showed strong antibacterial activity (21.0 ± 0.06 mm)… read more here.
Keywords: report steroid; steroid derivatives; first report; acanthaster planci ... See more keywords
Novel Endoperoxide Steroid Derivatives Containing Thiazole Moiety as Potential Antitumor Agents: Design, Synthesis, and Cytotoxic Evaluation
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DOI: 10.1177/1934578x231175588
Abstract: As part of the search for new steroid substances with potential application in oncology, a series of endoperoxide steroid derivatives (7a-n) containing a thiazole system were synthesized and evaluated for their cytotoxicities in four tumor… read more here.
Keywords: steroid derivatives; cytotoxic; containing thiazole; derivatives containing ... See more keywords