Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.16209
Abstract: Key Points Question Does steroid profiling combined with machine learning offer a potential 1-step strategy to facilitate diagnosis and subtype classification for treatment stratification of patients with primary aldosteronism? Findings This diagnostic study involving patients… read more here.
Keywords: steroid profiling; aldosteronism; machine learning; profiling combined ... See more keywords
UHPLC-HRMS Analysis for Steroid Profiling in Serum (Steroidomics).
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7643-0_18
Abstract: The extraction and untargeted UHPLC-HRMS analysis of endogenous steroids in serum samples is described in this protocol. The employed full-scan acquisition mode provides the adequate sensitivity to highlight the main endogenous steroids present in blood,… read more here.
Keywords: steroid profiling; uhplc hrms; hrms analysis; analysis steroid ... See more keywords
Potential of saliva steroid profiling for the detection of endogenous steroid abuse: Reference thresholds for oral fluid steroid concentrations and ratios.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.11.015
Abstract: Urine and blood samples are the primary matrices for the detection of exogenous substances in doping control and toxicology. Although these matrices are, in general, very suitable for a wide range of substances, they do… read more here.
Keywords: steroid profiling; oral fluid; saliva steroid; steroid ... See more keywords
Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.02.010
Abstract: The validated OECD test guideline 456 based on human adrenal H295R cells promotes measurement of testosterone and estradiol production as read-out to identify potential endocrine disrupting chemicals. This study aimed to establish optimal conditions for… read more here.
Keywords: steroid profiling; octyl methoxycinnamate; production; h295r ... See more keywords
Performance of mass spectrometry steroid profiling for diagnosis of polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Human Reproduction"
DOI: 10.1093/humrep/dew328
Abstract: STUDY QUESTION How well does multi-analyte steroid mass spectrometry (MS) profiling classify women with and without polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Our liquid chromatography MS (LC–MS) steroid profiling only minimally improves discrimination of women… read more here.
Keywords: steroid profiling; women without; polycystic ovary; mass spectrometry ... See more keywords
Steroid Profiling for Adrenocortical Disorders: A Pathway for Omics-Based Diagnostics.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical chemistry"
DOI: 10.1373/clinchem.2017.281048
Abstract: During the past 15 years, a considerable investment of effort and funds has been directed to the use of omics-based technologies for biomarker identification and development. The outcome in terms of laboratory tests applicable to… read more here.
Keywords: steroid profiling; profiling adrenocortical; omics based; mass spectrometry ... See more keywords