Studies on Steroid Receptor Coactivators in Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7845-8_15
Abstract: High expression of several androgen receptor coactivators is frequently reported in prostate cancer. Coactivators such as p300/CBP are involved in modulation of androgen receptor activity by increasing the effects of androgenic hormones and enhancing agonistic… read more here.
Keywords: prostate cancer; receptor; steroid receptor; receptor coactivators ... See more keywords
Steroid receptor coactivators present a unique opportunity for drug development in hormone‐dependent cancers
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.04.005
Abstract: &NA; Steroid receptor coactivators (SRCs) are essential regulators of nuclear hormone receptor function. SRCs coactivate transcription mediated by hormone stimulation of nuclear receptors and other transcription factors and have essential functions in human physiology and… read more here.
Keywords: hormone; coactivators present; receptor; steroid receptor ... See more keywords
Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31372-y
Abstract: Steroid receptor coactivator-2 (SRC-2) is a transcriptional coregulator that modulates the activity of many transcription factors. Levels of SRC-2 are elevated in endometrial biopsies from polycystic ovary syndrome patients, a population predisposed to endometrial cancer… read more here.
Keywords: ppp; endometrial cancer; cancer; rpia ... See more keywords
Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38MAPK-MK2 axis and affects NF-κB-mediated transcription
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68219-4
Abstract: Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several… read more here.
Keywords: transcription; steroid receptor; phosphorylation; p38mapk mk2 ... See more keywords
Steroid receptor coactivator-1 interacts with NF-κB to increase VEGFC levels in human thyroid cancer
Sign Up to like & getrecommendations! Published in 2018 at "Bioscience Reports"
DOI: 10.1042/bsr20180394
Abstract: Thyroid cancer is the most common endocrine cancer, and has a high incidence of lymphatic metastasis. Vascular endothelial growth factor C (VEGFC) is essential for development of lymphatic vessels and lymphatic metastases during carcinogenesis. Steroid… read more here.
Keywords: thyroid cancer; src; cancer; steroid receptor ... See more keywords
Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Chinese medical journal"
DOI: 10.1097/cm9.0000000000002537
Abstract: BACKGROUND Steroid receptor-associated and regulated protein (SRARP) suppresses tumor progression and modulates steroid receptor signaling by interacting with estrogen receptors and androgen receptors in breast cancer. In endometrial cancer (EC), progesterone receptor (PR) signaling is… read more here.
Keywords: tumor progression; steroid receptor; expression; receptor ... See more keywords
Role of steroid receptor and coregulator mutations in hormone-dependent cancers
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci88885
Abstract: Steroid hormones mediate critical lineage-specific developmental and physiologic responses. They function by binding their cognate receptors, which are transcription factors that drive specific gene expression programs. The requirement of most prostate cancers for androgen and… read more here.
Keywords: coregulator mutations; mutations hormone; role steroid; receptor ... See more keywords
Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family
Sign Up to like & getrecommendations! Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa232
Abstract: Abstract Multicellular organisms have evolved sophisticated mechanisms to recover and maintain original tissue functions following injury. Injury responses require a robust transcriptomic response associated with cellular reprogramming involving complex gene expression programs critical for effective… read more here.
Keywords: wound healing; healing related; related functions; tissue ... See more keywords
Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0482
Abstract: Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or overexpression has been identified in many cancers. In this… read more here.
Keywords: cancer; steroid receptor; receptor coactivator; coactivator ... See more keywords
A steroid receptor coactivator small molecule “stimulator” attenuates post-stroke ischemic brain injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1055295
Abstract: Introduction: Pathologic remodeling of the brain following ischemic stroke results in neuronal loss, increased inflammation, oxidative stress, astrogliosis, and a progressive decrease in brain function. We recently demonstrated that stimulation of steroid receptor coactivator 3… read more here.
Keywords: steroid receptor; injury; brain; receptor coactivator ... See more keywords
Steroid Receptor Signallings as Targets for Resveratrol Actions in Breast and Prostate Cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20051087
Abstract: Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the molecular mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors… read more here.
Keywords: signallings targets; steroid receptors; receptor signallings; prostate cancer ... See more keywords