Causes of early death in multiple myeloma patients treated with high-dose therapy followed by autologous stem cell transplantation: A study based on the nationwide Danish Multiple Myeloma Registry.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of hematology"
DOI: 10.1002/ajh.24857
Abstract: other day for 6 doses. This was followed by a maintenance dose of 120 mg/kg IV weekly for seven weeks in responding patients. Four patients received AAT as the first therapy option after demonstrating steroid-refractory… read more here.
Keywords: therapy; multiple myeloma; steroid refractory; gvhd ... See more keywords
Basiliximab for steroid‐refractory acute graft‐versus‐host disease: A real‐world analysis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26475
Abstract: Steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD) is one of the leading causes of early mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR‐aGVHD… read more here.
Keywords: basiliximab; steroid refractory; refractory acute; acute graft ... See more keywords
Health care utilization and steroid‐refractory toxicities from immune checkpoint inhibitors
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DOI: 10.1002/cncr.32542
Abstract: Anti–programmed death protein 1 (anti–PD‐1) agents have transformed the treatment of advanced melanoma and other cancers, but the rates of steroid‐refractory toxicities and health care utilization are not well described. This study assessed these endpoints… read more here.
Keywords: care utilization; refractory toxicities; health care; steroid refractory ... See more keywords
Donor T Cell Independent Mechanism May Contribute to Enhancing Steroid Refractory Gvhd in Murine Models
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.669
Abstract: Steroids are the first line therapy for acute GVHD but 50% of patients develop steroid refractory GVHD (SR-GVHD). The development of therapies for SR-GVHD is limited by incomplete understanding of its pathophysiology. Here we generated… read more here.
Keywords: steroid refractory; gvhd; donor cell; gvhd murine ... See more keywords
RNA Sequencing of Intestinal Biopsies Expands the T Cell-Centric Paradigm of Steroid-Refractory Acute Graft-Versus-Host Disease
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DOI: 10.1016/j.bbmt.2018.12.673
Abstract: Background Steroid-refractory acute GVHD (aGVHD) is a fatal disease with little known regarding its pathophysiology at the tissue level. We studied the gene expression profiles of onset and steroid-refractory aGVHD intestinal biopsies, including both supervised… read more here.
Keywords: intestinal biopsies; refractory acute; steroid refractory; cell ... See more keywords
Tocilizumab for the treatment of severe steroid-refractory acute graft-versus-host disease of the lower gastrointestinal tract
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DOI: 10.1038/s41409-018-0236-z
Abstract: Steroid-refractory (SR) acute gastrointestinal (GI) graft-versus-host disease (GVHD) is associated with significant mortality in allogeneic hematopoietic cell transplantation recipients. We retrospectively evaluated the efficacy of tocilizumab for the treatment of SR biopsy-proven acute lower GI… read more here.
Keywords: refractory acute; treatment; graft versus; versus host ... See more keywords
Necessity for treatment of steroid refractory severe GIT GVHD: patience of providers
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DOI: 10.1038/s41409-019-0630-1
Abstract: To the Editor, Steroid-refractory gastrointestinal tract (GIT) acute graft-versus-host disease (SR-aGVHD) remains one the most lethal complications of allogeneic hematopoietic cell transplantation (HCT), with a mortality rate upwards of 75% [1, 2]. Despite the utility… read more here.
Keywords: gvhd; treatment steroid; steroid refractory; git gvhd ... See more keywords
Long-term outcomes of ruxolitinib therapy in steroid-refractory graft-versus-host disease in children and adults
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DOI: 10.1038/s41409-020-0834-4
Abstract: Acute and chronic steroid-refractory graft-versus-host disease (srGVHD) is a life-threatening complication of allogeneic stem cell transplantation. There are a number of reports on case series describing efficacy of ruxolitinib in both acute and chronic srGVHD.… read more here.
Keywords: steroid refractory; disease; refractory graft; graft versus ... See more keywords
Long-term outcomes and risk factor analysis of steroid-refractory graft versus host disease after hematopoietic stem cell transplantation
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DOI: 10.1038/s41409-020-0977-3
Abstract: Steroid-refractory graft versus host disease (GVHD) represents a fearsome complication after allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a retrospective study on outcomes and risk factors associated with acute and chronic steroid-refractory GVHD in… read more here.
Keywords: steroid refractory; disease; transplantation; gvhd ... See more keywords
Steroid-refractory ulcerative colitis: a critical review of national and international guideline recommendations.
Sign Up to like & getrecommendations! Published in 2021 at "Zeitschrift fur Gastroenterologie"
DOI: 10.1055/a-1482-9273
Abstract: Es gibt zahlreiche nationale und internationale Leitlinien zu chronisch entzündlichen Darmerkrankungen, die auf vergleichbarer Evidenz sowie ähnlichen Prozeduren beruhen und daher homogen sein sollten. In dieser kritischen Übersicht wurden die Leitlinienempfehlungen aus Europa (ECCO), Deutschland,… read more here.
Keywords: die; colitis critical; refractory ulcerative; colitis ... See more keywords
Ruxolitinib for steroid-refractory graft versus host disease in pediatric HSCT: high response rate and manageable toxicity
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DOI: 10.1080/08880018.2020.1868637
Abstract: Abstract Ruxolitinib, a selective Janus Kinase (JAK) 1/2 inhibitor, is a promising treatment for the steroid-refractory graft-vs-host disease (GvHD) after hematopoietic stem cell transplantation (HSCT). Most studies have been performed in the adult population showing… read more here.
Keywords: response; cgvhd; toxicity; oncology ... See more keywords