MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01291-5
Abstract: (Patho-)physiological activation of the IL7-receptor (IL7R) signaling contributes to steroid resistance in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Here, we show that activating IL7R pathway mutations and physiological IL7R signaling activate MAPK-ERK signaling, which provokes… read more here.
Keywords: steroid resistance; acute lymphoblastic; cell acute; mapk erk ... See more keywords
Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation
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DOI: 10.1111/resp.13052
Abstract: Severe asthma has significant disease burden and results in high healthcare costs. While existing therapies are effective for the majority of asthma patients, treatments for individuals with severe asthma are often ineffective. Mouse models are… read more here.
Keywords: mouse models; severe asthma; disease; disease exacerbation ... See more keywords
Clinical and Apoptotic Factors Defining and Predicting Steroid Resistance in Nephrotic Syndrome in Children
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DOI: 10.1177/2333794x221085392
Abstract: Introduction. Nephrotic syndrome (NS) is a kidney disease characterized by albuminuria, hyperlipidemia, edema, and hypoalbuminemia. Above 20 % of nephrotic children do not show response to steroid treatment. Molecular markers controlling apoptosis have not been… read more here.
Keywords: factors defining; serum; caspase; nephrotic syndrome ... See more keywords
Effect of Tissue Transglutaminase on Steroid Resistance in T-Cell Acute Lymphoblastic Leukemia
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DOI: 10.21873/anticanres.13824
Abstract: Aim: To improve survival in patients with glucocorticoid-resistant T-cell acute lymphoblastic leukemia (T-ALL), it is critical to develop new therapeutic strategies to overcome steroid resistance. Materials and Methods: Biochemical and molecular methodologies were used to… read more here.
Keywords: cell acute; lymphoblastic leukemia; steroid resistance; resistance ... See more keywords
STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL and BCLXL following glucocorticoid treatment
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.280405
Abstract: Physiological and pathogenic interleukin-7-receptor (IL7R)-induced signaling provokes glucocorticoid resistance in a subset of patients with pediatric T-cell acute lymphoblastic leukemia (T-ALL). Activation of downstream STAT5 has been suggested to cause steroid resistance through upregulation of… read more here.
Keywords: cell; stat5; steroid resistance; resistance ... See more keywords
Steroid Resistance Associated with High MIF and P-gp Serum Levels in SLE Patients
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DOI: 10.3390/molecules27196741
Abstract: Approximately 30% of patients with systemic lupus erythematosus (SLE) present steroid resistance (SR). Macrophage migration inhibition factor (MIF) and P-glycoprotein (P-gp) could be related to SR. This work aims to evaluate the relationship between MIF… read more here.
Keywords: mif serum; serum levels; factor; steroid resistance ... See more keywords