Biomarker profile predicts clinical efficacy of extracorporeal photopheresis in steroid‐resistant acute and chronic graft‐vs‐host disease after allogenic hematopoietic stem cell transplant
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21918
Abstract: We conducted a multicenter interventional study to assess the efficacy of Therakos ECP to treat steroid‐resistant graft‐vs‐host disease (SRes‐GVHD) after allogeneic HSCT and to identify biomarkers of GVHD response. A total of 62 patients were… read more here.
Keywords: response; sres gvhd; graft host; steroid resistant ... See more keywords
Genetic analysis and outcomes of Omani children with steroid-resistant nephrotic syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular genetics & genomic medicine"
DOI: 10.1002/mgg3.2201
Abstract: BACKGROUND Nephrotic syndrome (NS) is one of the most common kidney disorders seen by pediatric nephrologists and is defined by the presence of heavy proteinuria (>3.5 g/24 h), hypoalbuminemia ( read more here.
Keywords: omani children; resistant nephrotic; syndrome; steroid resistant ... See more keywords
Treatment of steroid-resistant nephrotic syndrome in the genomic era
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-4093-1
Abstract: The pathogenesis of steroid-resistant nephrotic syndrome (SRNS) is not completely known. Recent advances in genomics have elucidated some of the molecular mechanisms and pathophysiology of the disease. More than 50 monogenic causes of SRNS have… read more here.
Keywords: treatment steroid; resistant nephrotic; nephrotic syndrome; steroid resistant ... See more keywords
Dominant PAX2 mutations may cause steroid-resistant nephrotic syndrome and FSGS in children
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Nephrology"
DOI: 10.1007/s00467-019-04256-0
Abstract: BackgroundHeterozygous PAX2 mutations cause renal coloboma syndrome (RCS) [OMIM no. 120330]. RCS is a renal syndromic disease encompassing retinal coloboma and sensorineural hearing loss. Recently, a causative role for PAX2 was reported in adult-onset nephrotic… read more here.
Keywords: resistant nephrotic; steroid resistant; pax2 mutations; fsgs ... See more keywords
Immunosuppressive therapy for steroid-resistant nephrotic syndrome: a Bayesian network meta-analysis of randomized controlled studies
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Nephrology"
DOI: 10.1007/s10157-017-1484-8
Abstract: BackgroundThe purpose of this study was to conduct a meta-analysis examining the efficacy of cyclophosphamide, cyclosporin, and tacrolimus in treating steroid resistant nephrotic syndrome.MethodsMedline, Cochrane, EMBASE, and Google Scholar were searched until May 02, 2017… read more here.
Keywords: immunosuppressive therapy; resistant nephrotic; meta analysis; analysis ... See more keywords
The RNA-binding protein Mex-3B plays critical roles in the development of steroid-resistant neutrophilic airway inflammation.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.158
Abstract: While most asthma can be treated with steroids, about 10%, called severe asthma, is refractory to steroids. It has recently been shown that in a subgroup of severe asthma cases, neutrophils that infiltrate into the… read more here.
Keywords: resistant neutrophilic; inflammation; airway inflammation; steroid resistant ... See more keywords
Various phenotypes of disease associated with mutated DGKE gene.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2020.103953
Abstract: Atypical haemolytic uraemic syndrome and steroid-resistant nephrotic syndrome are highlyrare kidney diseases that can occur in childhood. In some cases, genetic variants may trigger these conditions, although in atypical haemolytic uraemic syndrome they mostly confer… read more here.
Keywords: resistant nephrotic; uraemic syndrome; atypical haemolytic; steroid resistant ... See more keywords
Effect of Combined Gluten-Free, Dairy-Free Diet in Children With Steroid-Resistant Nephrotic Syndrome: An Open Pilot Trial
Sign Up to like & getrecommendations! Published in 2018 at "Kidney International Reports"
DOI: 10.1016/j.ekir.2018.02.011
Abstract: Introduction Steroid-resistant nephrotic syndrome (SRNS) affects both children and adults and has a high rate of progression to end-stage renal disease. Although a subset of patients have well-characterized genetic mutation(s), in the majority of cases,… read more here.
Keywords: trial; nephrotic syndrome; steroid resistant; effect ... See more keywords
Mutations in KIRREL1, a slit diaphragm component, cause steroid-resistant nephrotic syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.06.016
Abstract: Steroid-resistant nephrotic syndrome is a frequent cause of chronic kidney disease almost inevitably progressing to end-stage renal disease. More than 58 monogenic causes of SRNS have been discovered and majority of known steroid-resistant nephrotic syndrome… read more here.
Keywords: slit diaphragm; resistant nephrotic; mutations kirrel1; nephrotic syndrome ... See more keywords
Anti-α4β7 integrin monoclonal antibody (vedolizumab) for the treatment of steroid-resistant severe intestinal acute graft-versus-host disease
Sign Up to like & getrecommendations! Published in 2018 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-018-0364-5
Abstract: Steroid-resistant (SR) acute graft-versus-host disease (aGvHD) is a life-threatening complication of allogeneic stem cell transplantation. Vedolizumab is a monoclonal antibody that impairs homing of T cells to the gastrointestinal (GI) endothelium by blocking the α4β7… read more here.
Keywords: treatment; disease; steroid resistant; versus ... See more keywords
Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study
Sign Up to like & getrecommendations! Published in 2020 at "Nature Medicine"
DOI: 10.1038/s41591-020-1050-x
Abstract: The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been investigated in diverse diseases 1 , including steroid-resistant acute graft versus host disease (SR-aGvHD) 2 . However, conventional manufacturing approaches are hampered by challenges… read more here.
Keywords: mesenchymal stromal; derived mesenchymal; stromal cells; steroid resistant ... See more keywords