Recent progress in the development of steroid sulphatase inhibitors – examples of the novel and most promising compounds from the last decade
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1758692
Abstract: Abstract The purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulphatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones… read more here.
Keywords: steroid sulphatase; examples novel; progress development; recent progress ... See more keywords
New potent steroid sulphatase inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2020.1858820
Abstract: Abstract In the present work, we report a new class of potent steroid sulphatase (STS) inhibitors based on 6-(1-phenyl-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate derivatives. Within the set of new STS inhibitors, 6-(1-(1,2,3-trifluorophenyl)-1H-1,2,3-triazol-4-yl)naphthalen-2-yl sulphamate 3L demonstrated the highest activity… read more here.
Keywords: steroid sulphatase; triazol naphthalen; inhibitors based; naphthalen sulphamate ... See more keywords
SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0045
Abstract: Steroid sulphatase is an emerging drug target for the endocrine therapy of hormone-dependent diseases, catalysing oestrogen sulphate hydrolysis to oestrogen. Drug discovery, developing the core aryl O-sulphamate pharmacophore, has led to steroidal and non-steroidal drugs… read more here.
Keywords: steroid sulphatase; sulphatase inhibition; inhibition; drug ... See more keywords