Increase in tacrolimus exposure after steroid tapering is influenced by CYP3A5 and pregnane X receptor genetic polymorphisms in renal transplant recipients
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DOI: 10.1093/ndt/gfy096
Abstract: Background Tacrolimus, a drug for prevention of rejection after kidney transplantation, has a narrow therapeutic window and is metabolized by the cytochrome P540 3A (CYP3A) system. Tacrolimus exposure increases after steroid tapering in many patients.… read more here.
Keywords: steroid tapering; increase; tacrolimus exposure; renal transplant ... See more keywords