Biotransformation Enables Innovations toward Green Synthesis of Steroidal Pharmaceuticals.
Sign Up to like & getrecommendations! Published in 2022 at "ChemSusChem"
DOI: 10.1002/cssc.202102399
Abstract: Steroids have been widely used in birth-control, prevention and treatment of various diseases, representing the largest sector after antibiotics in the global pharmaceutical market. The steroidal active pharmaceutical ingredients (APIs) have been produced via partial… read more here.
Keywords: production; biotransformation enables; synthesis steroidal; steroidal ... See more keywords
Enrichment of total steroidal saponins from the extracts of Trillium tschonoskii Maxim by macroporous resin and the simultaneous determination of eight steroidal saponins in the final product by HPLC.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of separation science"
DOI: 10.1002/jssc.201600884
Abstract: An effective and simple method was established for the separation and enrichment of steroidal saponins from Trillium tschonoskii Maxim. The adsorption and desorption properties of seven macroporous resins were investigated. Among the tested resins, AB-8… read more here.
Keywords: steroidal saponins; final product; steroidal; trillium tschonoskii ... See more keywords
Non-targeted LC-MS based metabolomics analysis of the urinary steroidal profile.
Sign Up to like & getrecommendations! Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.01.055
Abstract: The urinary steroidal fraction has been extensively explored as non-invasive alternative to monitor pathological conditions as well as to unveil the illicit intake of pseudo-endogenous anabolic steroids in sport. However, the majority of previous approaches… read more here.
Keywords: urinary steroidal; steroidal; analysis urinary; targeted based ... See more keywords
Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112909
Abstract: 17beta-Hydroxysteroid dehydrogenase type 10 (17β-HSD10) is the only mitochondrial member of 17β-HSD family. This enzyme can oxidize estradiol (E2) into estrone (E1), thus reducing concentration of this neuroprotective steroid. Since 17β-HSD10 possesses properties that suggest… read more here.
Keywords: steroidal; hydroxysteroid dehydrogenase; metabolic stability; dehydrogenase type ... See more keywords
Multi-step synthesis, spectroscopic studies of biological active steroidal thiosemicarbazones and their palladium (II) complex as macromolecules.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.08.141
Abstract: Steroidal Pd (II) metal complexes were synthesized by the reaction of steroidal thiosemicarbazones with [Pd (DMSO)2 Cl2]. The steroidal thiosemicarbazones coordinate to palladium through the azomethine nitrogen and thionic sulfur. The thiosemicarbazone derivatives were obtained… read more here.
Keywords: steroidal; spectroscopic; steroidal thiosemicarbazones; macromolecules multi ... See more keywords
Five new steroidal saponins from the seeds of Solanum melongena L.
Sign Up to like & getrecommendations! Published in 2021 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2020.10.008
Abstract: Abstract Two novel cholestane-type steroidal saponins, melongoside R-S (1-2) and three novel furostanol-type steroidal saponins, melongoside T-V (3-5), together with three known steroidal saponins (6-8) were isolated from the seeds of Solanum melongna L. The… read more here.
Keywords: steroidal saponins; new steroidal; steroidal; seeds solanum ... See more keywords
Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032620
Abstract: Steroidal saponins are an important type of plant-specific metabolite that are essential for plants’ responses to biotic and abiotic stresses. Because of their extensive pharmacological activities, steroidal saponins are also important industrial raw materials for… read more here.
Keywords: steroidal; saponins plants; steroidal saponins; molecular evolution ... See more keywords