Functional Expression and Construction of a Self‐Sufficient Cytochrome P450 Chimera for Efficient Steroidal C14α Hydroxylation in Escherichia coli
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DOI: 10.1002/bit.28911
Abstract: C14‐functionalized steroids enabled diverse biological activities in anti‐gonadotropin and anticancer therapy. However, access to C14‐functionalized steroids was impeded by the deficiency of chemical synthetic methods. Recently, several membrane‐bound fungal cytochrome P450s (CYPs) have been identified… read more here.
Keywords: escherichia coli; c14 hydroxylation; steroidal c14; c14 ... See more keywords