Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs.
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DOI: 10.1016/j.ejmech.2017.10.063
Abstract: Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and estrone, decorated with spiranic oxazolidin-2-one or 2-aminooxazoline motifs at C-17 as potential antiproliferative agents. Such unprecedented pharmacophores were accessed using an aminomethylalcohol… read more here.
Keywords: steroidal spiro; cell lines; potential antiproliferative; unprecedented steroidal ... See more keywords