Long‐term nanoplastics exposure contributes to impaired steroidogenesis by disrupting the hypothalamic‐testis axis: Evidence from integrated transcriptome and metabolome analysis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4696
Abstract: Cumulative evidence suggested that nanoplastics (NPs) cause male toxicity, but the mechanisms of which are still misty. Steroidogenesis is a key biological event that responsible for maintaining reproductive health. However, whether dysregulated steroidogenesis is involved… read more here.
Keywords: steroidogenesis; nps; long term; transcriptome metabolome ... See more keywords
Taurine Recovers Testicular Steroidogenesis and Spermatogenesis in Streptozotocin-Induced Diabetic Rats.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1079-2_62
Abstract: A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine… read more here.
Keywords: steroidogenesis; testicular steroidogenesis; diabetic rats; steroidogenesis spermatogenesis ... See more keywords
Long-term 1-nitropyrene exposure induces endoplasmic reticulum stress and inhibits steroidogenesis in mice testes.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126336
Abstract: 1-Nitropyrene (1-NP) is a representative nitro-polycyclic aromatic hydrocarbon from diesel exhaust. Recently, we found that maternal 1-NP exposure caused fetal growth retardation and disturbed cognitive development in adolescent female offspring. To investigate long-term 1-NP exposure… read more here.
Keywords: long term; exposure; steroidogenesis; mice ... See more keywords
Estrogenic potency of MC-LR is induced via stimulating steroidogenesis: In vitro and in vivo evidence.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.04.140
Abstract: Waterborne microcystin-LR (MC-LR) has been reported to disrupt sex hormones, while its estrogenic potency remains controversial. We hypothesized that MC-LR could induce estrogenic effects via disrupting sex hormone synthesis, and verified this hypothesis by in vitro… read more here.
Keywords: vitro vivo; estrogenic potency; steroidogenesis;
Venlafaxine-induced adrenergic signaling stimulates Leydig cells steroidogenesis via Nur77 overexpression: a possible role of EGF.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120069
Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of… read more here.
Keywords: egf; venlafaxine; venlafaxine induced; steroidogenesis ... See more keywords
Pde8b haploinsufficiency in mice is associated with modest adrenal defects, impaired steroidogenesis, and male infertility, unaltered by concurrent PKA or Wnt activation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111117
Abstract: PDE8B, PRKAR1A and the Wnt/β-catenin signaling are involved in endocrine disorders. However, how PDEB8B interacts with both Wnt and protein kinase A (PKA) signaling in vivo remains unknown. We created a novel Pde8b knockout mouse… read more here.
Keywords: pde8b; wnt; prkar1a; steroidogenesis ... See more keywords
Impairment of renal steroidogenesis at the onset of diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111170
Abstract: Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and the development of diabetic nephropathy. However, the renal synthesis of steroid hormones during diabetes is essentially unknown. Male Wistar rats were… read more here.
Keywords: steroidogenesis onset; stz; onset diabetes; impairment renal ... See more keywords
The effects and possible mechanisms of triclosan on steroidogenesis in primary rat granulosa cells.
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.11.001
Abstract: BACKGROUND Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. METHODS Primary rat granulosa cells (rGCs) were… read more here.
Keywords: granulosa cells; rat granulosa; primary rat; steroidogenesis ... See more keywords
Exposure to Boscalid Induces Reproductive Toxicity of Zebrafish by Gender-Specific Alterations in Steroidogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental science & technology"
DOI: 10.1021/acs.est.0c02871
Abstract: Boscalid is a succinate dehydrogenase inhibitor fungicide and is frequently detected in surface water. Due to the frequent detection of boscalid, we evaluated its impact on the reproduction of adult zebrafish following a 21 d… read more here.
Keywords: gender specific; exposure boscalid; zebrafish; exposure ... See more keywords
Machine Learning and Large Language Models for Modeling Complex Toxicity Pathways and Predicting Steroidogenesis.
Sign Up to like & getrecommendations! Published in 2025 at "Environmental science & technology"
DOI: 10.1021/acs.est.5c04054
Abstract: High-throughput screening and computational models have been effective in predicting chemical interactions with estrogen and androgen receptors, but similar approaches for steroidogenesis remain limited. To address this gap, we developed general steroidogenesis modulation models using… read more here.
Keywords: large language; steroidogenesis; learning large; machine learning ... See more keywords
Perturbing local steroidogenesis to improve breast cancer immunity
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59356-3
Abstract: Breast cancer, particularly triple-negative breast cancer (TNBC), evades the body’s immune defences, in part by cultivating an immunosuppressive tumour microenvironment. Here, we show that suppressing local steroidogenesis can augment anti-tumour immunity against TNBC. Through targeted… read more here.
Keywords: local steroidogenesis; breast cancer; steroidogenesis; immunity ... See more keywords