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Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-94-024-1079-2_62
Abstract: A great deal of investigations have verified that diabetic male reproductive impairment is associated with the dysfunction of testicular steroidogenesis and spermatogenesis resulted from insulin deficiency and hyperglycaemia-induced oxidative stress. It has been identified taurine…
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Keywords:
steroidogenesis;
testicular steroidogenesis;
diabetic rats;
steroidogenesis spermatogenesis ... See more keywords
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Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.126336
Abstract: 1-Nitropyrene (1-NP) is a representative nitro-polycyclic aromatic hydrocarbon from diesel exhaust. Recently, we found that maternal 1-NP exposure caused fetal growth retardation and disturbed cognitive development in adolescent female offspring. To investigate long-term 1-NP exposure…
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Keywords:
long term;
exposure;
steroidogenesis;
mice ... See more keywords
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Published in 2018 at "Environmental pollution"
DOI: 10.1016/j.envpol.2018.04.140
Abstract: Waterborne microcystin-LR (MC-LR) has been reported to disrupt sex hormones, while its estrogenic potency remains controversial. We hypothesized that MC-LR could induce estrogenic effects via disrupting sex hormone synthesis, and verified this hypothesis by in vitro…
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Keywords:
vitro vivo;
estrogenic potency;
steroidogenesis;
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Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.120069
Abstract: Venlafaxine, a norepinephrine and serotonin reuptake inhibitor, impairs rat sperm parameters, spermatogenesis and causes high intratesticular estrogen and testosterone levels, indicating that Leydig cells (LCs) may be a venlafaxine target. We evaluated the effect of…
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Keywords:
egf;
venlafaxine;
venlafaxine induced;
steroidogenesis ... See more keywords
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Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111117
Abstract: PDE8B, PRKAR1A and the Wnt/β-catenin signaling are involved in endocrine disorders. However, how PDEB8B interacts with both Wnt and protein kinase A (PKA) signaling in vivo remains unknown. We created a novel Pde8b knockout mouse…
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Keywords:
pde8b;
wnt;
prkar1a;
steroidogenesis ... See more keywords
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Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111170
Abstract: Accumulating evidence indicates the association between changes in circulating sex steroid hormone levels and the development of diabetic nephropathy. However, the renal synthesis of steroid hormones during diabetes is essentially unknown. Male Wistar rats were…
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Keywords:
steroidogenesis onset;
stz;
onset diabetes;
impairment renal ... See more keywords
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Published in 2019 at "Reproductive toxicology"
DOI: 10.1016/j.reprotox.2018.11.001
Abstract: BACKGROUND Triclosan (TCS) has been detected in human tissues. It can disrupt steroidogenesis in vivo. The study on the effects of TCS on ovarian granulosa cells was lacking. METHODS Primary rat granulosa cells (rGCs) were…
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Keywords:
granulosa cells;
rat granulosa;
primary rat;
steroidogenesis ... See more keywords
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Published in 2020 at "Environmental science & technology"
DOI: 10.1021/acs.est.0c02871
Abstract: Boscalid is a succinate dehydrogenase inhibitor fungicide and is frequently detected in surface water. Due to the frequent detection of boscalid, we evaluated its impact on the reproduction of adult zebrafish following a 21 d…
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Keywords:
gender specific;
exposure boscalid;
zebrafish;
exposure ... See more keywords
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Published in 2017 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2016.1272094
Abstract: Abstract A comprehensive weight-of-the-evidence evaluation of 2,4-dichlorophenoxyacetic acid (2,4-D) was conducted for potential interactions with the estrogen, androgen and thyroid pathways and with steroidogenesis. This assessment was based on an extensive database of high quality…
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Keywords:
androgen;
evidence;
steroidogenesis;
estrogen androgen ... See more keywords
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Published in 2017 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2017.1296046
Abstract: ABSTRACT Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder of women of reproductive age characterized by polycystic ovarian morphology, anovulation or oligomenorrhea, and hyperandrogenism. It is shown that disruption in the steroidogenesis pathway…
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Keywords:
granulosa cells;
polycystic ovarian;
steroidogenesis;
vitamin ... See more keywords
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Published in 2022 at "Systems Biology in Reproductive Medicine"
DOI: 10.1080/19396368.2022.2033350
Abstract: Abstract Diabetes mellitus induced hyperglycemia increases oxidative stress, which contributes to impairment of male reproductive function. Aquaporins (AQPs) belong to a transmembrane protein superfamily containing 13 isoforms (AQP0-12), differentially expressed in various organs, and play…
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Keywords:
steroidogenesis;
oxidative stress;
testicular steroidogenesis;
leydig cell ... See more keywords