Subcellular localization of sterol biosynthesis enzymes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-018-9807-y
Abstract: Cholesterol synthesis is a complex, coordinated process involving a series of enzymes. As of today, our understanding of subcellular localization of cholesterol biosynthesis enzymes is far from complete. Considering the complexity and intricacies of this… read more here.
Keywords: biosynthesis; biosynthesis enzymes; subcellular localization; sterol biosynthesis ... See more keywords
Design, Synthesis, and Evaluation of Novel 4-Chloropyrazole-Based Pyridines as Potent Fungicide Candidates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02350
Abstract: A rational molecular design approach was developed in our laboratory to guide the discovery of novel sterol biosynthesis inhibitors. Based on the application of bioactivities of heterocyclic rings and molecular docking targeting the sterol biosynthesis… read more here.
Keywords: sterol biosynthesis; novel; design; chloropyrazole based ... See more keywords
Paleoproterozoic sterol biosynthesis and the rise of oxygen
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21412
Abstract: Natural products preserved in the geological record can function as ‘molecular fossils’, providing insight into organisms and physiologies that existed in the deep past. One important group of molecular fossils is the steroidal hydrocarbons (steranes),… read more here.
Keywords: biosynthesis; oxygen; sterol biosynthesis; gyr ago ... See more keywords
A phosphorylated transcription factor regulates sterol biosynthesis in Fusarium graminearum
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09145-6
Abstract: Sterol biosynthesis is controlled by transcription factor SREBP in many eukaryotes. Here, we show that SREBP orthologs are not involved in the regulation of sterol biosynthesis in Fusarium graminearum, a fungal pathogen of cereal crops… read more here.
Keywords: transcription; biosynthesis; fusarium graminearum; transcription factor ... See more keywords
The selective estrogen receptor modulator clomiphene inhibits sterol biosynthesis in Arabidopsis thaliana.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of experimental botany"
DOI: 10.1093/jxb/erae481
Abstract: Sterols are produced via complex, multistep biosynthetic pathways involving similar enzymatic conversions in plants, animals and fungi, yielding a variety of sterol metabolites with slightly different chemical properties to exert diverse and specific functions. A… read more here.
Keywords: plant; estrogen receptor; sterol biosynthesis; biosynthesis ... See more keywords
Exploiting in silico structural analysis to introduce emerging genotype–phenotype correlations in DHCR24-related sterol biosynthesis disorder: a case study
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1307934
Abstract: Desmosterolosis is a rare sterol biosynthesis disorder characterized by multiple congenital anomalies, failure to thrive, severe developmental delay, progressive epileptic encephalopathy, and elevated levels of desmosterol caused by biallelic mutations of DHCR24 encoding 3-β-hydroxysterol Δ-24-reductase.… read more here.
Keywords: biosynthesis disorder; genotype phenotype; dhcr24 related; disorder ... See more keywords
Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12101535
Abstract: Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ). As the effects of psychotropic medications are… read more here.
Keywords: effects psychotropic; ari trz; biosynthesis; sterol biosynthesis ... See more keywords
Sterol uptake and sterol biosynthesis act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2018.8716
Abstract: Pathogenic fungi, including Candida glabrata, develop strategies to grow and survive both in vitro and in vivo under azole stress. However, the mechanisms by which yeast cells counteract the inhibitory effects of azoles are not… read more here.
Keywords: biosynthesis; glabrata; sterol biosynthesis; stress ... See more keywords
Novel [1,2,3]triazolo[1,5-a]pyridine derivatives are trypanocidal by sterol biosynthesis pathway alteration.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0242
Abstract: Aim: To study a new series of [1,2,3]triazolo[1,5-α]pyridine derivatives as trypanocidal agents because current antichagasic pharmacologic therapy is only partially effective. Materials & methods: The effect of the series upon Trypanosoma cruzi epimastigotes and murine… read more here.
Keywords: biosynthesis pathway; triazolo pyridine; sterol biosynthesis; derivatives trypanocidal ... See more keywords