An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.044
Abstract: The azole antifungal drugs are an important class of chemotherapeutic agents with broad-spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic pathway through inhibition of the cytochrome P450-dependent enzyme sterol 14α-demethylase.… read more here.
Keywords: sterol demethylase; antileishmanial therapy; sterol; chemistry ... See more keywords
Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02098-16
Abstract: ABSTRACT Chagas disease is a life-threatening infection caused by a variety of genetically diverse strains of the protozoan parasite Trypanosoma cruzi. The current treatment (benznidazole and nifurtimox) is unsatisfactory, and potential alternatives include inhibitors of… read more here.
Keywords: sterol demethylase; cruzi; demethylase cyp51; cyp51 ... See more keywords
Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in Leishmania major
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DOI: 10.1371/journal.ppat.1008810
Abstract: Sterol 14-α-demethylase (C14DM) is a key enzyme in the biosynthesis of sterols and the primary target of azoles. In Leishmania major, genetic or chemical inactivation of C14DM leads to accumulation of 14-methylated sterol intermediates and… read more here.
Keywords: leishmania major; sterol demethylase; demethylase vital; sterol ... See more keywords