Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure
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DOI: 10.1128/aac.01044-21
Abstract: The azole antifungals inhibit sterol 14α-demethylase (S14DM), leading to depletion of cellular ergosterol and the synthesis of an aberrant sterol diol that disrupts membrane function. In Candida albicans, sterol diol production is catalyzed by the… read more here.
Keywords: sterol desaturase; desaturase; species specific; sterol diol ... See more keywords