Repurposing of FDA-approved drugs as inhibitors of sterol C-24 methyltransferase of Leishmania donovani to fight against leishmaniasis.
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DOI: 10.1002/ddr.21820
Abstract: Leishmaniasis is a vector-borne disease caused by around 20 species of Leishmania. The main clinical forms of leishmaniasis are cutaneous leishmaniasis (CL) and visceral leishmaniasis (VL). VL is caused by Leishmania infantum in Central and… read more here.
Keywords: sterol methyltransferase; leishmaniasis; drug; donovani ... See more keywords
Widespread Sterol Methyltransferase Participates in the Biosynthesis of Both C4α- and C4β-Methyl Sterols
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DOI: 10.1021/jacs.2c01401
Abstract: The 4-methyl steranes serve as molecular fossils and are used for studying both eukaryotic evolution and geological history. The occurrence of 4α-methyl steranes in sediments has long been considered evidence of products of partial demethylation… read more here.
Keywords: methyl steranes; sterol methyltransferase; methyl; methyl sterols ... See more keywords
Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase
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DOI: 10.3389/fcimb.2022.859981
Abstract: The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory molecules. Leishmania donovani 24-sterol methyltransferase (LdSMT) is vital for the synthesis of… read more here.
Keywords: sterol methyltransferase; donovani sterol; homology modeling; identify potential ... See more keywords