Inhibition of the sterol regulatory element‐binding protein pathway suppresses hepatocellular carcinoma by repressing inflammation in mice
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29018
Abstract: Obesity is a critical risk factor for hepatocellular carcinoma (HCC). However, it remains unknown whether inhibition of de novo lipid biosynthesis can suppress HCC. In this study, we blocked the sterol regulatory element‐binding protein (SREBP)… read more here.
Keywords: hepatocellular carcinoma; inhibition; regulatory element; pathway ... See more keywords
Regulatory roles of sterol regulatory element-binding protein (SREBP) on lipid metabolism in marine invertebrate Chlamys nobilis.
Sign Up to like & getrecommendations! Published in 2018 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2018.03.023
Abstract: Abstract Sterol regulatory element-binding protein (SREBP) has mainly been studied in vertebrates in which lipogenesis is regulated in both liver and adipose tissue. There is, however, a paucity of information on bivalves, in which lipogenesis… read more here.
Keywords: regulatory element; srebp; protein srebp; binding protein ... See more keywords
Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.02.006
Abstract: Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia.… read more here.
Keywords: regulatory element; element binding; sterol regulatory; cancer ... See more keywords
Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09152-7
Abstract: Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid biosynthesis and adipogenesis by controlling the expression of several enzymes required for cholesterol, fatty acid, triacylglycerol and phospholipid synthesis. In… read more here.
Keywords: metabolism; regulatory element; mechanical cues; sterol regulatory ... See more keywords
Evolutionary analysis of buffalo sterol regulatory element-binding factor (SREBF) family genes and their affection on milk traits.
Sign Up to like & getrecommendations! Published in 2022 at "Animal biotechnology"
DOI: 10.1080/10495398.2022.2070185
Abstract: The sterol regulatory element-binding factor (SREBF) genes are a vital group of proteins binding to the sterol regulatory element 1 (SRE-1) regulating the synthesis of fatty acid. Two potential candidate genes (SREBF1 and SREBF2) have… read more here.
Keywords: srebf family; family genes; milk; srebf genes ... See more keywords
Sterol regulatory element binding protein‐1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer
Sign Up to like & getrecommendations! Published in 2017 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13106
Abstract: Women with polycystic ovary syndrome have a three‐fold higher risk of endometrial cancer. Insulin resistance and hyperlipidemia may be pertinent factors in the pathogenesis of both conditions. The aim of this study was to investigate… read more here.
Keywords: polycystic ovary; regulatory element; endometrial cancer; ovary syndrome ... See more keywords
MON-108 Dihydrotestosterone Lowers Cytosolic Sterol Regulatory Element-Binding Protein-1 in Adipose Tissue from Female Mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-mon-108
Abstract: Abstract Abstract: Hyperandrogenemia (HA) and insulin resistance (IR) are hallmarks of polycystic ovary syndrome (PCOS), a common endocrine disorder that affects roughly 1 in 5 women, according to the Rotterdam criteria. These hallmarks are also… read more here.
Keywords: mice; sterol regulatory; regulatory element; low dose ... See more keywords
Regulation of Expression of Sterol Regulatory Element-binding Protein 1 in Thyroid Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.15727
Abstract: Background/Aim: Expression of sterol regulatory element-binding protein 1 (SREBP1) is upregulated in thyroid cancer and associated with shorter disease-specific survival. The molecular regulatory mechanisms governing SREBP1 over-expression in thyroid cancer are still unclear. Materials and… read more here.
Keywords: expression sterol; expression; thyroid cancer; srebp1 expression ... See more keywords
Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.01788
Abstract: Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play… read more here.
Keywords: medicine; regulatory element; role; sterol regulatory ... See more keywords
Leptin Silencing Attenuates Lipid Accumulation through Sterol Regulatory Element-Binding Protein 1 Inhibition in Nasopharyngeal Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105700
Abstract: Leptin is a crucial regulator of metabolism and energy homeostasis in mammals. Many studies have investigated the impacts of leptin on human cancers, such as proliferation and metastasis. However, the mechanisms underlying leptin-mediated regulation of… read more here.
Keywords: nasopharyngeal carcinoma; regulatory element; element binding; leptin ... See more keywords