Sequential One-Pot Carbene-Catalyzed Intramolecular Stetter Reaction and Acid-Mediated Condensation: Access to Heteroatom Analogues of π-Extended Polyaromatic Hydrocarbons.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02693
Abstract: In this Letter, we disclose a simple and effective method to access a variety of phenanthro[9,10-b]furan and 1H-dibenzo[e,g]indole derivatives based on the design of a carbene-catalyzed intramolecular Stetter reaction followed by a Paal-Knorr reaction in… read more here.
Keywords: stetter reaction; catalyzed intramolecular; reaction; one pot ... See more keywords
Synthesis of Novel 1,4-Diketone Derivatives and Their Further Cyclization
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DOI: 10.1021/acsomega.3c00610
Abstract: One of the important reactions to obtain a new carbon–carbon bond is the Stetter reaction, which is generally via a nucleophilic catalyst like cyanide or thiazolium-NHC catalysts. In particular, 1,4-diketones with very functional properties are… read more here.
Keywords: stetter reaction; reaction; cyclization; synthesis novel ... See more keywords
A cyanide-catalyzed imino-Stetter reaction enables the concise total syntheses of rucaparib
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DOI: 10.1039/d2ra03619c
Abstract: Two routes toward the synthesis of rucaparib, an FDA-approved drug used for the treatment of ovarian and prostate cancers, have been developed from commercially available starting materials utilizing the cyanide-catalyzed imino-Stetter reaction as the key… read more here.
Keywords: stetter reaction; imino stetter; reaction; synthesis ... See more keywords
Remote electronic effect on the N-heterocyclic carbene-catalyzed asymmetric intramolecular Stetter reaction and structural revision of products.
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DOI: 10.1039/d3cc00693j
Abstract: The remote electronic effects of chiral N-heterocyclic carbene catalysts on the asymmetric intramolecular Stetter reaction are investigated. The reaction rate and enantioselectivity were markedly influenced by a substituent at a remote position of the catalyst.… read more here.
Keywords: stetter reaction; asymmetric intramolecular; remote electronic; reaction ... See more keywords
Total Syntheses of 2,2′-Biindolyl Alkaloids via Cyanide-Catalyzed Imino-Stetter Reaction
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DOI: 10.1055/a-2069-3913
Abstract: 2,2’-Biindolyl natural products have a long history of applications owing to their unique structural features and biological activities. In this account, we describe the recent progress achieved by our research group in the total syntheses… read more here.
Keywords: stetter reaction; imino stetter; reaction; catalyzed imino ... See more keywords