Sticker-and-spacer model for amyloid beta condensation and fibrillation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.962526
Abstract: A major pathogenic hallmark of Alzheimer’s disease is the presence of neurotoxic plaques composed of amyloid beta (Aβ) peptides in patients’ brains. The pathway of plaque formation remains elusive, though some clues appear to lie… read more here.
Keywords: amyloid beta; sticker spacer; model; spacer model ... See more keywords
Dynamic metastable long-living droplets formed by sticker-spacer proteins
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.56159
Abstract: Multivalent biopolymers phase separate into membrane-less organelles (MLOs) which exhibit liquid-like behavior. Here, we explore formation of prototypical MOs from multivalent proteins on various time and length scales and show that the kinetically arrested metastable… read more here.
Keywords: long living; living droplets; sticker spacer; formed sticker ... See more keywords