Cholesterol‐regulated cellular stiffness may enhance evasion of NK cell‐mediated cytotoxicity in gastric cancer stem cells
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13793
Abstract: Gastric cancer has a high rate of recurrence, and as such, immunotherapy strategies are being investigated as a potential therapeutic strategy. Although the involvement of immune checkpoints in immunotherapy is well studied, biomechanical cues, such… read more here.
Keywords: cancer; gastric cancer; cell; cell mediated ... See more keywords
Exploiting Geometric Frustration in Coupled von Mises Trusses to Program Multifunctional Mechanical Metamaterials
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Engineering Materials"
DOI: 10.1002/adem.202402006
Abstract: Multistable mechanical metamaterials are an emerging class of materials whose intricate internal structure can be engineered to program mechanical properties and promote reversible transitions between multiple stable states of energy. In this work, the design… read more here.
Keywords: stable states; mechanical metamaterials; geometric frustration; von mises ... See more keywords
Lightweight Self‐Forming Super‐Elastic Mechanical Metamaterials with Adaptive Stiffness
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202008252
Abstract: Scarcity of stiff, yet compliant materials is a major obstacle toward biological-like mechanical systems that perform precise manipulations while being resilient under excessive load. We introduce a macroscopic cellular structure comprising of two pre-stressed elastic… read more here.
Keywords: adaptive stiffness; stiffness; super elastic; self forming ... See more keywords
Low Melting Point Alloys Enabled Stiffness Tunable Advanced Materials
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202201942
Abstract: Stiffness tunable advanced materials have demonstrated their superiority and versatility in diverse areas, while the global pursuit of reversible, intelligent, and fast response for stiffness regulation is growing radically, leaving great challenges for traditional materials.… read more here.
Keywords: stiffness tunable; stiffness; tunable advanced; enabled stiffness ... See more keywords
Calmodulin‐Based Dynamic Protein Hydrogels with Three Distinct Mechanical Stiffness
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202404934
Abstract: Stimuli‐responsive hydrogels that leverage protein conformational changes are of significant interest in the design of dynamic materials applicable in a myriad of fields, such as drug delivery, actuators, biosensors, and microfluidics. The small calcium binding… read more here.
Keywords: based dynamic; three distinct; protein; stiffness ... See more keywords
Tensegrity‐Inspired Pre‐Stress Control for Programmable Multistability and Stiffness in Mechanical Metamaterials
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202420892
Abstract: Mechanical metamaterials have considerable application potential, but are often limited to single applications owing to material and manufacturing constraints. To achieve a “single structure, multiple applications” goal, this study presents a multifunctional metamaterial structure. The… read more here.
Keywords: control; structure; mechanical metamaterials; stress ... See more keywords
Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201600967
Abstract: Dynamic alterations of composition and mechanics of the extracellular matrix are suggested to modulate cellular behavior including plasticity of macrophages (MPhs) during wound healing. In this study, engineered 3D fibrillar matrices based on naturally occurring… read more here.
Keywords: wound healing; stiffness; instructing human; macrophage polarization ... See more keywords
Mechanical Response of Neural Cells to Physiologically Relevant Stiffness Gradients
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.201901036
Abstract: Abstract Understanding the influence of the mechanical environment on neurite behavior is crucial in the development of peripheral nerve repair solutions, and could help tissue engineers to direct and guide regeneration. In this study, a… read more here.
Keywords: response neural; stiffness; mechanical response; physiologically relevant ... See more keywords
3D Printed Dual-porosity Scaffolds: the Combined Effect of Stiffness and Porosity in the Modulation of Macrophage Polarization.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101415
Abstract: Tissue regeneration evolves towards the biofabrication of sophisticated 3D scaffolds. However, the success of these will be contingent to their capability to integrate within the host. The control of the mechanical or topographical properties of… read more here.
Keywords: dual porosity; porosity; modulation; printed dual ... See more keywords
Tuning Polymer Hydrophilicity to Regulate Gel Mechanics and Encapsulated Cell Morphology
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200011
Abstract: Mechanically tunable hydrogels are attractive platforms for 3D cell culture, as hydrogel stiffness plays an important role in cell behavior. Traditionally, hydrogel stiffness has been controlled through altering either the polymer concentration or the stoichiometry… read more here.
Keywords: cell morphology; cell; stiffness; mechanics ... See more keywords
A Polymer Canvas with the Stiffness of the Bone Matrix to Study and Control Mesenchymal Stem Cell Response
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201503
Abstract: Reproducing in vitro the complex multiscale physical features of human tissues creates novel biomedical opportunities and fundamental understanding of cell−environment interfaces and interactions. While stiffness has been recognized as a key driver of cell behavior,… read more here.
Keywords: cell; polymer canvas; stiffness bone; stiffness ... See more keywords