A novel STIM1-Orai1 gating interface essential for CRAC channel activation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.02.009
Abstract: Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel. STIM1, a key molecular component… read more here.
Keywords: orai1 gating; stim1; crac channel; stim1 orai1 ... See more keywords
Calcium oscillations in fertilized pig oocytes are associated with repetitive interactions between STIM1 and ORAI1†
Sign Up to like & getrecommendations! Published in 2018 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioy016
Abstract: ABSTRACT The Ca2+ entry mechanism that sustains the Ca2+ oscillations in fertilized pig oocytes was investigated. Stromal interaction molecule 1 (STIM1) and ORAI1 proteins tagged with various fluorophores were expressed in the oocytes. In some… read more here.
Keywords: oscillations fertilized; stim1; stim1 orai1; ca2 ... See more keywords
Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-5947-z
Abstract: BackgroundThe endoplasmic reticulum (ER) Ca2+ sensor, stromal interaction molecule1 (STIM1) activates the plasma membrane (PM) channel Orai1 in order to mediate store-operated Ca2+ entry (SOCE) in response to ER store depletion. Enhanced expression of STIM1… read more here.
Keywords: expression stim1; stim1; stim1 orai1; ca2 ... See more keywords
Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection
Sign Up to like & getrecommendations! Published in 2020 at "Biology"
DOI: 10.3390/biology9110388
Abstract: Simple Summary In this study, we systematically evaluated the genetic susceptibility between the store-operated calcium (SOC) influx pathway (stromal interaction molecule 1 (STIM1) and ORAI1) and human hepatocellular carcinoma (HCC) in patients with chronic hepatitis… read more here.
Keywords: store operated; hcc; stim1 orai1; chronic hepatitis ... See more keywords
STIM1–Orai1 Interaction Exacerbates LPS-Induced Inflammation and Endoplasmic Reticulum Stress in Bovine Hepatocytes through Store-Operated Calcium Entry
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13050874
Abstract: (1) Background: The basic mechanism of store-operated Ca2+ entry (SOCE) in bovine hepatocytes (BHEC) is related to the activation of STIM1 and Orai1. The effect of STIM1- and Orai1-dependent calcium ion signaling on the NF-κB… read more here.
Keywords: inflammation; induced inflammation; bovine hepatocytes; lps induced ... See more keywords