Epigallocatechin-3-O-gallate promotes extracellular matrix and inhibits inflammation in IL-1β stimulated chondrocytes by the PTEN/miRNA-29b pathway
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DOI: 10.1080/13880209.2022.2039722
Abstract: Abstract Context Epigallocatechin-3-O-gallate (EGCG) exhibits anti-arthritic activity. MiR-29b-3p provokes chondrocyte apoptosis and promotes the initiation and development of osteoarthritis (OA). Objective To explore the roles of EGCG and miR-29b-3p in interleukin-1β (IL-1β)-stimulated chondrocytes. Materials and… read more here.
Keywords: mir 29b; matrix; epigallocatechin gallate; stimulated chondrocytes ... See more keywords
Characterization and role exploration of ferroptosis-related genes in osteoarthritis
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DOI: 10.3389/fmolb.2023.1066885
Abstract: Osteoarthritis (OA), viewing as a degenerative aseptic inflammatory disease, is characterized by joint pain and inflammation that significantly affects the quality of patients’ life, especially for the elder. Although rapid progress has been achieved in… read more here.
Keywords: ferroptosis related; characterization role; related genes; ferroptosis ... See more keywords
Knockdown of lncRNA JPX suppresses IL-1β-stimulated injury in chondrocytes through modulating an miR-25-3p/PPID axis
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DOI: 10.3892/ol.2022.13508
Abstract: The aim of this study was to investigate the potential mechanisms of long noncoding (lnc) RNA Just proximal to X-inactive specific transcript (JPX) in interleukin (IL)-1β-stimulated chondrocytes. Human C28/I2 chondrocytes were treated with IL-1β to… read more here.
Keywords: stimulated injury; jpx knockdown; mir; injury ... See more keywords