Interferon stimulated genes and innate immune activation following infection with hepatitis B and C viruses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24659
Abstract: Although not directly cytopathic, hepatitis B and C viruses (HBV and HCV) are responsible for millions of deaths per year, and the aging patient population presents a severe public health challenge. Most cases of acute… read more here.
Keywords: hepatitis viruses; hepatitis; genes innate; activation ... See more keywords
Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0511-1
Abstract: Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles… read more here.
Keywords: ifn; interferon; activation; type ... See more keywords
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.085
Abstract: The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG… read more here.
Keywords: ddx6; activation; stimulated genes; interferon stimulated ... See more keywords
ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/1248201
Abstract: Activation of the interferon (IFN) pathway in response to infection with pathogens results in the induction of IFN-stimulated genes (ISGs) including proinflammatory cytokines, which mount the proper antiviral immune response. However, aberrant expression of these… read more here.
Keywords: znf395; response; ifn stimulated; activation ... See more keywords
Hot topic: Pregnancy-induced expression of interferon-stimulated genes in the cervical and vaginal mucosal membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dairy science"
DOI: 10.3168/jds.2017-14251
Abstract: In ruminants, IFN-tau (IFNT) is a pregnancy recognition signal secreted by the embryonic trophectoderm before implantation, and it induces the expression of IFN-stimulated genes (ISG) in the uterine endometrium and blood leukocytes. The expression of… read more here.
Keywords: pregnancy; cervical vaginal; expression; stimulated genes ... See more keywords
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.605024
Abstract: Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication. RNA viruses are frequently targeted by ISGs through recognition… read more here.
Keywords: rna; rna processes; interferon; translation ... See more keywords
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1008072
Abstract: Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression products have various biological functions, such as antiviral and immunomodulatory effects, and… read more here.
Keywords: central nervous; system cns; expression; stimulated genes ... See more keywords
Interferon and interferon-stimulated genes in HBV treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1034968
Abstract: Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is the causative agent of acute and chronic hepatitis. HBV can resist immune system responses and often causes… read more here.
Keywords: interferon; hbv treatment; stimulated genes; treatment ... See more keywords
Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v10040162
Abstract: Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide, with variations in NDV pathogenicity due to the differences in virulence between strains. However, there is limited… read more here.
Keywords: disease virus; stimulated genes; virus; newcastle disease ... See more keywords
Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11030246
Abstract: The antiviral activity of type I interferons (IFNs) is primarily mediated by interferon-stimulated genes (ISGs). Induction of ISG transcription is achieved when type I IFNs bind to their cognate receptor and activate the Janus Kinase/Signal… read more here.
Keywords: hcmv infection; infection; expression; stimulated genes ... See more keywords
Human Cytomegalovirus UL23 Antagonizes the Antiviral Effect of Interferon-γ by Restraining the Expression of Specific IFN-Stimulated Genes
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15041014
Abstract: Interferon-γ (IFN-γ) is a critical component of innate immune responses in humans to combat infection by many viruses, including human cytomegalovirus (HCMV). IFN-γ exerts its biological effects by inducing hundreds of IFN-stimulated genes (ISGs). In… read more here.
Keywords: effect; ifn stimulated; expression; ifn ... See more keywords