Interferon stimulated genes and innate immune activation following infection with hepatitis B and C viruses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24659
Abstract: Although not directly cytopathic, hepatitis B and C viruses (HBV and HCV) are responsible for millions of deaths per year, and the aging patient population presents a severe public health challenge. Most cases of acute… read more here.
Keywords: hepatitis viruses; hepatitis; genes innate; activation ... See more keywords
Identification of new type I interferon-stimulated genes and investigation of their involvement in IFN-β activation
Sign Up to like & getrecommendations! Published in 2018 at "Protein & Cell"
DOI: 10.1007/s13238-018-0511-1
Abstract: Virus infection induces the production of type I interferons (IFNs). IFNs bind to their heterodimeric receptors to initiate downstream cascade of signaling, leading to the up-regulation of interferon-stimulated genes (ISGs). ISGs play very important roles… read more here.
Keywords: ifn; interferon; activation; type ... See more keywords
DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.085
Abstract: The innate immune system tightly regulates activation of interferon-stimulated genes (ISGs) to avoid inappropriate expression. Pathological ISG activation resulting from aberrant nucleic acid metabolism has been implicated in autoimmune disease; however, the mechanisms governing ISG… read more here.
Keywords: ddx6; activation; stimulated genes; interferon stimulated ... See more keywords
The Myc-associated zinc finger protein epigenetically controls expression of interferon-γ-stimulated genes by recruiting STAT1 to chromatin
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2320938121
Abstract: Significance The MYC-Associated Zinc Finger Protein (MAZ) plays a pivotal role in regulation of gene transcription. Dysregulation of MAZ expression has been linked to a range of debilitating diseases, including glioblastoma, liposarcoma, and cancers. Here,… read more here.
Keywords: zinc finger; associated zinc; myc associated; stimulated genes ... See more keywords
ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes
Sign Up to like & getrecommendations! Published in 2017 at "Mediators of Inflammation"
DOI: 10.1155/2017/1248201
Abstract: Activation of the interferon (IFN) pathway in response to infection with pathogens results in the induction of IFN-stimulated genes (ISGs) including proinflammatory cytokines, which mount the proper antiviral immune response. However, aberrant expression of these… read more here.
Keywords: znf395; response; ifn stimulated; activation ... See more keywords
The History of Interferon-Stimulated Genes (ISGs) in Pregnant Cattle, Sheep, and Pigs.
Sign Up to like & getrecommendations! Published in 2024 at "Reproduction"
DOI: 10.1530/rep-24-0130
Abstract: Expression of the classical interferon (IFN) stimulated genes (ISGs) increases in the endometrial stroma and glandular epithelium (GE) through activation of signal transducer and activator of transcription (STAT) signaling in response to the secretion of… read more here.
Keywords: history; interferon; genes isgs; expression ... See more keywords
Hot topic: Pregnancy-induced expression of interferon-stimulated genes in the cervical and vaginal mucosal membranes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of dairy science"
DOI: 10.3168/jds.2017-14251
Abstract: In ruminants, IFN-tau (IFNT) is a pregnancy recognition signal secreted by the embryonic trophectoderm before implantation, and it induces the expression of IFN-stimulated genes (ISG) in the uterine endometrium and blood leukocytes. The expression of… read more here.
Keywords: pregnancy; cervical vaginal; expression; stimulated genes ... See more keywords
All About the RNA: Interferon-Stimulated Genes That Interfere With Viral RNA Processes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.605024
Abstract: Interferon (IFN) signaling induces the expression of a wide array of genes, collectively referred to as IFN-stimulated genes (ISGs) that generally function to inhibit viral replication. RNA viruses are frequently targeted by ISGs through recognition… read more here.
Keywords: rna; rna processes; interferon; translation ... See more keywords
Expression and mechanisms of interferon-stimulated genes in viral infection of the central nervous system (CNS) and neurological diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1008072
Abstract: Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression products have various biological functions, such as antiviral and immunomodulatory effects, and… read more here.
Keywords: central nervous; system cns; expression; stimulated genes ... See more keywords
Interferon and interferon-stimulated genes in HBV treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1034968
Abstract: Human hepatitis B virus (HBV) is a small enveloped DNA virus with a complex life cycle. It is the causative agent of acute and chronic hepatitis. HBV can resist immune system responses and often causes… read more here.
Keywords: interferon; hbv treatment; stimulated genes; treatment ... See more keywords
Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v10040162
Abstract: Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide, with variations in NDV pathogenicity due to the differences in virulence between strains. However, there is limited… read more here.
Keywords: disease virus; stimulated genes; virus; newcastle disease ... See more keywords