An INS‐1 832/13 𝛽‐Cell Proteome Highlights the Rapid Regulation of Fatty Acid Biosynthesis in Glucose‐Stimulated Insulin Secretion
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DOI: 10.1002/pmic.70005
Abstract: Pancreatic beta cells secrete insulin in response to rising glucose levels, a process known as glucose‐stimulated insulin secretion (GSIS). Here, we acquire proteomes of rat pancreatic INS‐1 832/13 beta cells that were short‐term stimulated with… read more here.
Keywords: stimulated insulin; secretion; ins 832; glucose stimulated ... See more keywords
In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography
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DOI: 10.1038/s41467-024-45648-7
Abstract: Actin mediates insulin secretion in pancreatic β-cells through remodeling. Hampered by limited resolution, previous studies have offered an ambiguous depiction as depolymerization and repolymerization. We report the in situ structure of actin remodeling in INS-1E… read more here.
Keywords: insulin secretion; stimulated insulin; secretion; actin remodeling ... See more keywords
Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
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DOI: 10.1038/s41598-020-58411-x
Abstract: We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts… read more here.
Keywords: if1; insulin secretion; native if1; stimulated insulin ... See more keywords
Islet NO-Synthases, extracellular NO and glucose-stimulated insulin secretion: Possible impact of neuronal NO-Synthase on the pentose phosphate pathway
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DOI: 10.1371/journal.pone.0315126
Abstract: The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in… read more here.
Keywords: glucose; stimulated insulin; pathway; glucose stimulated ... See more keywords
Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells
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DOI: 10.2147/dmso.s240794
Abstract: Purpose To investigate the effect of geniposide on the biosynthesis of insulin and the expression protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductin 1 (ERO1) in the presence of low (5 mM) and high (25… read more here.
Keywords: pancreatic cells; redox signaling; glucose stimulated; glucose ... See more keywords
Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function
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DOI: 10.2337/db21-0037
Abstract: The defining feature of pancreatic islet β-cell function is the precise coordination of changes in blood glucose levels with insulin secretion to regulate systemic glucose homeostasis. While ATP has long been heralded as a critical… read more here.
Keywords: insulin secretion; stimulated insulin; cell function; glucose stimulated ... See more keywords
941-P: Epiallopregnanolone Sulfate Is Reduced in Gestational Diabetes Mellitus and Induces Glucose-Stimulated Insulin Secretion
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DOI: 10.2337/db21-941-p
Abstract: Introduction: Serum progesterone sulfate (P4S) concentrations increase in pregnancy and bind receptors that influence glucose homeostasis. We hypothesized that P4S modulate glucose homeostasis in pregnancy. Methods: Serum P4S were assayed using ultra-performance liquid chromatography- tandem… read more here.
Keywords: insulin secretion; stimulated insulin; glucose stimulated; none ... See more keywords
282-OR: Pancreatic Alpha Cells Integrate Neuronal and Immune Stimuli for Insulin Secretion
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DOI: 10.2337/db25-282-or
Abstract: Introduction and Objective: Neuronal stimulation can trigger insulin secretion, as seen in the cephalic phase insulin response (CPIR). The CPIR is the release of insulin in the anticipation of a meal and occurs prior to… read more here.
Keywords: insulin secretion; none; stimulated insulin; secretion ... See more keywords
Daily Injection of the β2 Adrenergic Agonist Clenbuterol Improved Muscle Glucose Metabolism, Glucose-Stimulated Insulin Secretion, and Hyperlipidemia in Juvenile Lambs Following Heat-Stress-Induced Intrauterine Growth Restriction
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DOI: 10.3390/metabo14030156
Abstract: Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction (IUGR) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that… read more here.
Keywords: insulin secretion; clenbuterol; iugr lambs; muscle glucose ... See more keywords
(1′S)-1′-Acetoxyeugenol Acetate Enhances Glucose-Stimulated Insulin Secretion
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DOI: 10.3390/plants12030579
Abstract: Alpinia galanga have been widely used as spice or traditional medicine in East Asia, commonly known as Thai ginger. In the present study, seven major phenylpropanoids, (±)-1′-hydoxychavicol acetate (1; HCA), (1′S)-1′-acetoxychavicol acetate (2; ACA), (1′S)-1′-acetoxyeugenol… read more here.
Keywords: stimulated insulin; acetoxyeugenol acetate; acetate; insulin secretion ... See more keywords