Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells
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DOI: 10.1038/s41598-020-58411-x
Abstract: We have previously reported that transient knock-down of ATPase inhibitory factor 1 (IF1) by siRNA upregulates ATP levels and subsequently augments insulin secretion in model pancreatic β-cells INS-1E. Here we investigated how long-term IF1-overexpression impacts… read more here.
Keywords: if1; insulin secretion; native if1; stimulated insulin ... See more keywords
Geniposide Balances the Redox Signaling to Mediate Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s240794
Abstract: Purpose To investigate the effect of geniposide on the biosynthesis of insulin and the expression protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductin 1 (ERO1) in the presence of low (5 mM) and high (25… read more here.
Keywords: pancreatic cells; redox signaling; glucose stimulated; glucose ... See more keywords
Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function
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DOI: 10.2337/db21-0037
Abstract: The defining feature of pancreatic islet β-cell function is the precise coordination of changes in blood glucose levels with insulin secretion to regulate systemic glucose homeostasis. While ATP has long been heralded as a critical… read more here.
Keywords: insulin secretion; stimulated insulin; cell function; glucose stimulated ... See more keywords
941-P: Epiallopregnanolone Sulfate Is Reduced in Gestational Diabetes Mellitus and Induces Glucose-Stimulated Insulin Secretion
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DOI: 10.2337/db21-941-p
Abstract: Introduction: Serum progesterone sulfate (P4S) concentrations increase in pregnancy and bind receptors that influence glucose homeostasis. We hypothesized that P4S modulate glucose homeostasis in pregnancy. Methods: Serum P4S were assayed using ultra-performance liquid chromatography- tandem… read more here.
Keywords: insulin secretion; stimulated insulin; glucose stimulated; none ... See more keywords
(1′S)-1′-Acetoxyeugenol Acetate Enhances Glucose-Stimulated Insulin Secretion
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DOI: 10.3390/plants12030579
Abstract: Alpinia galanga have been widely used as spice or traditional medicine in East Asia, commonly known as Thai ginger. In the present study, seven major phenylpropanoids, (±)-1′-hydoxychavicol acetate (1; HCA), (1′S)-1′-acetoxychavicol acetate (2; ACA), (1′S)-1′-acetoxyeugenol… read more here.
Keywords: stimulated insulin; acetoxyeugenol acetate; acetate; insulin secretion ... See more keywords