Identification of Molecular Determinants in iRhoms1 and 2 That Contribute to the Substrate Selectivity of Stimulated ADAM17
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DOI: 10.3390/ijms232112796
Abstract: The metalloprotease ADAM17 is a key regulator of the TNFα, IL-6R and EGFR signaling pathways. The maturation and function of ADAM17 is controlled by the seven-membrane-spanning proteins iRhoms1 and 2. The functional properties of the… read more here.
Keywords: adam17; stimulated shedding; substrate selectivity; shedding adam17 ... See more keywords