Prognostic Impact of Stimulator of Interferon Genes Expression in Triple Negative Breast Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70666
Abstract: Patients with triple negative breast cancer (TNBC) who have a poor response to neoadjuvant chemotherapy (NAC) have worse survival and new treatment strategies need to be developed. TNBC is considered a subtype in which the… read more here.
Keywords: cancer; breast cancer; negative breast; interferon genes ... See more keywords
Stimulator of interferon genes (STING) inhibits coronavirus infection by disrupting viral replication organelles
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70020
Abstract: Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER) protein that plays a crucial role in cytosolic DNA‐mediated innate immunity. Both STING agonists and antagonists have demonstrated their ability to enhance mouse survival against… read more here.
Keywords: replication; genes sting; coronavirus infection; interferon genes ... See more keywords
Stimulator of Interferon Genes Regulates Ferroptosis and Airway Inflammation via acyl-CoA Synthetase Long-Chain Family Member 4 in Asthmatic Mice.
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02338-w
Abstract: Ferroptosis is closely associated with the various pathological manifestations of asthma. This study aimed to explore the role of the stimulator of interferon genes (STING) in modulating airway inflammation in asthma, with a particular focus… read more here.
Keywords: ferroptosis airway; airway inflammation; acyl coa; interferon genes ... See more keywords
Identification and function analysis of canine stimulator of interferon gene (STING)
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Pathogenesis"
DOI: 10.1016/j.micpath.2017.10.047
Abstract: Abstract Stimulator of interferon gene (STING) plays an important role in the cyclic GMP-AMP synthase (cGAS)-mediated activation of type I IFN responses. In this study, we identified and cloned canine STING gene. Full-length STING encodes… read more here.
Keywords: stimulator interferon; gene sting; canine; interferon gene ... See more keywords
The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135972
Abstract: Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by the accumulation of pathogenic phosphorylated α-synuclein in oligodendrocytes. In brains affected by MSA, severe astrogliosis is also observed, but its precise role in MSA… read more here.
Keywords: stimulator interferon; system atrophy; interferon genes; sting pathway ... See more keywords
Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01795
Abstract: Stimulator of interferon genes (STING) is an endoplasmic reticulum-membrane protein that plays important roles in cancer immunotherapy by activating innate immune responses. We designed and synthesized STING modulators and characterized compounds 4a and 4c that… read more here.
Keywords: development potent; potent immune; stimulator interferon; interferon ... See more keywords
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01948
Abstract: The activation of the cyclic GMP-AMP synthase-stimulator of interferon gene (STING) pathway has been associated with the pathogenesis of many autoimmune and inflammatory disorders, and small molecules targeting STING have emerged as a new therapeutic… read more here.
Keywords: crbn; stimulator interferon; anti inflammatory; proteolysis targeting ... See more keywords
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02197
Abstract: Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) pathway, is were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular potency, along with computational,… read more here.
Keywords: interferon genes; stimulator interferon; discovery 1454; cyclic dinucleotide ... See more keywords
Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01567
Abstract: Stimulator of interferon genes (STING) is an endoplasmic reticulum-localized adaptor protein (STING receptor) that has been shown to be activated by binding to natural cyclic dinucleotide (CDN) ligands and plays a vital role in innate… read more here.
Keywords: stimulator interferon; amidobenzimidazole; interferon genes; genes sting ... See more keywords
Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy via Amplifying Stimulator of Interferon Genes Activation.
Sign Up to like & getrecommendations! Published in 2025 at "ACS nano"
DOI: 10.1021/acsnano.4c15115
Abstract: The stimulator of interferon genes (STING) pathway exhibits great potential in remodeling the immunosuppressive tumor microenvironment and initiating antitumor immunity. However, how to effectively activate STING and avoid undesired toxicity after systemic administration remains challenging.… read more here.
Keywords: mno2np; activation; interferon genes; tumor ... See more keywords
An updated patent review of stimulator of interferon genes agonists (2021 – present)
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2024.2365409
Abstract: ABSTRACT Introduction Stimulator of Interferon Genes (STING) is an innate immune sensor. Activation of STING triggers a downstream response that results in the expression of proinflammatory cytokines (TNF-α, IL-1β) via nuclear factor kappa-B (NF-κB) or… read more here.
Keywords: interferon; interferon genes; sting agonists; stimulator interferon ... See more keywords