Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the experimental analysis of behavior"
DOI: 10.1002/jeab.740
Abstract: Nicotine produces robust stimulus effects that can be conditioned to exert stimulus control over behavior through associative learning. Additionally, nicotine has weak reinforcing effects that are inconsistent with its prevalence of use and the tenacity… read more here.
Keywords: stimulus effects; appetitive pavlovian; effects nicotine; pavlovian conditioning ... See more keywords
Discriminative Stimulus Effects of Abused Inhalants.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2016_22
Abstract: Inhalants are a loosely organized category of abused compounds defined entirely by their common route of administration. Inhalants include volatile solvents, fuels, volatile anesthetics, gasses, and liquefied refrigerants, among others. They are ubiquitous in modern… read more here.
Keywords: abused inhalants; stimulus effects; discriminative stimulus; pharmacology ... See more keywords
Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2017_2
Abstract: The progress on understanding the pharmacological basis of ethanol's discriminative stimulus effects has been substantial, but appears to have plateaued in the past decade. Further, the cross-species translational efforts are clear in laboratory animals, but… read more here.
Keywords: species translational; cross species; stimulus effects; discriminative stimulus ... See more keywords
Locomotor activity and discriminative stimulus effects of a novel series of synthetic cathinone analogs in mice and rats
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4562-4
Abstract: RationaleRecent years have seen an increase in the recreational use of novel, synthetic psychoactive substances. There are little or no data on the abuse liability of many of the newer compounds.ObjectivesThe current study investigated the… read more here.
Keywords: series synthetic; locomotor activity; stimulus effects; discriminative stimulus ... See more keywords
Understanding the stimulus effects of nicotine and bupropion in a drug-drug discriminated goal-tracking task.
Sign Up to like & getrecommendations! Published in 2022 at "Psychopharmacology"
DOI: 10.1007/s00213-022-06072-1
Abstract: RATIONALE Bupropion is a non-nicotine medication for smoking cessation that has overlapping stimulus effects with nicotine as demonstrated in drug discrimination studies. Whether these shared stimulus effects will alter acquisition or maintenance of a discrimination… read more here.
Keywords: stimulus effects; effects nicotine; discrimination; drug ... See more keywords
Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.01.020
Abstract: &NA; One emerging strategy to address the opioid crisis is the development of mu opioid receptor (MOR) ligands that preferentially signal the G‐protein vs. &bgr;‐arrestin pathway. The present study compared the relative potency and effectiveness… read more here.
Keywords: tail withdrawal; protein biased; stimulus effects; mor ... See more keywords
Distinct cognitive and discriminative stimulus effects of ketamine enantiomers in rats
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2020.173011
Abstract: Although (S)-ketamine was approved for use in treatment-resistant patients in 2019, new preclinical findings suggest that (R)-ketamine might produce better efficacy and tolerability relative to (S)-ketamine. Here we evaluated the effects of (R)-, (S)-, and… read more here.
Keywords: ketamine; stimulus effects; discriminative stimulus; effects ketamine ... See more keywords
Locomotor and discriminative stimulus effects of four novel hallucinogens in rodents
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000309
Abstract: There has been increasing use of novel synthetic hallucinogenic compounds, 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25B-NBOMe), 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25C-NBOMe), 2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine hydrochloride (25I-NBOMe), and N,N-diallyl-5-methoxy tryptamine (5-MeO-DALT), which have been associated with severe toxicities. These four compounds were tested… read more here.
Keywords: 25i nbome; fully substituted; dom; nbome fully ... See more keywords
The discriminative stimulus effects of baclofen and gamma hydroxybutyrate in C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000691
Abstract: Baclofen and γ-hydroxybutyrate (GHB) exert γ-aminobutyric acid (GABA)B receptor agonism and have therapeutic utility but possess different pharmacological activities. We examined whether separate groups of mice could be trained to discriminate either baclofen or GHB,… read more here.
Keywords: appropriate responding; discriminative stimulus; stimulus effects; ghb ... See more keywords
Cocaine‐like discriminative stimulus effects of alpha‐pyrrolidinovalerophenone, methcathinone and their 3,4‐methylenedioxy or 4‐methyl analogs in rhesus monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Addiction Biology"
DOI: 10.1111/adb.12399
Abstract: Synthetic cathinones are beta‐ketone amphetamine analogs that have emerged as a heterogeneous class of abused compounds that function as either monoamine transporter substrates or inhibitors. Pre‐clinical drug discrimination procedures are useful for interrogating structure–activity relationships… read more here.
Keywords: stimulus effects; discriminative stimulus; cocaine like; cocaine ... See more keywords
Methylenedioxymethamphetamine-like discriminative stimulus effects of pyrrolidinyl cathinones in rats
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881120914213
Abstract: Background: Synthetic cathinone derivatives are used as alternatives both for stimulant drugs such as cocaine and methamphetamine and for club drugs such as 3,4-methylenedioxymethamphetamine (MDMA), but little is known about their MDMA-like subjective effects. Methods… read more here.
Keywords: pyrrolidinyl cathinones; carbons produced; stimulus effects; discriminative stimulus ... See more keywords