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   Articles with "sting activating" as a keyword



In Situ STING-Activating Nanovaccination with TIGIT Blockade for Enhanced Immunotherapy of Anti-PD-1-Resistant Tumors.

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recommendations! Published in 2023 at "Advanced materials"

DOI: 10.1002/adma.202300171

Abstract: Immunotherapies comprising programmed cell death protein 1/PD ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors are effective cancer treatments. However, the low response rate and immunoresistance resulting from alternative immune checkpoint upregulation and inefficient immune stimulation by… read more here.

Keywords: situ sting; cell; activating nanovaccination; sting activating ... See more keywords

STING‐Activating Polymers Boost Lymphatic Delivery of mRNA Vaccine to Potentiate Cancer Immunotherapy

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recommendations! Published in 2024 at "Advanced Materials"

DOI: 10.1002/adma.202412654

Abstract: The unprecedented success of mRNA vaccines against COVID‐19 has inspired scientists to develop mRNA vaccines for cancer immunotherapy. However, using nucleoside modified mRNA as vaccine, though evading innate immune toxicity, diminishes its therapeutic efficacy for… read more here.

Keywords: cancer; cancer immunotherapy; mrna vaccine; sting activating ... See more keywords

Long-Acting In Situ Cancer Vaccines by Oncolytic STING-Activating Microgels.

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recommendations! Published in 2025 at "Small"

DOI: 10.1002/smll.202503561

Abstract: In situ cancer vaccines exploiting endogenous multiple antigens directly from tumors to elicit broad immune responses hold great potential in cancer treatment. However, the feeble antigen presentation and hostile immune microenvironments pose severe challenges to… read more here.

Keywords: cancer; situ cancer; activating microgels; cancer vaccines ... See more keywords

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.04.003

Abstract: There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we report that STING-activating cyclic dinucleotides (CDNs) formulated in a protein subunit vaccine elicit long-lasting… read more here.

Keywords: protection; sting activating; adjuvants elicit; immune response ... See more keywords