STING activation enhances cetuximab-mediated NK cell activation and DC maturation and correlates with HPV+ status in head and neck cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2018.01.019
Abstract: Objectives The intracellular DNA sensor stimulator of interferon genes (STING) has recently been shown to play a vital role in anti-viral and anti-tumor immune responses stimulating cytokine production. While human papillomavirus (HPV) is a causative… read more here.
Keywords: sting activation; cetuximab mediated; activation; cancer ... See more keywords
Apoptotic Body-Mediated Intracellular Delivery Strategy for Enhanced STING Activation and Improved Tumor Immunogenicity.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c03996
Abstract: Agonists of stimulators of interferon genes (STING) are a promising class of immunotherapeutics that trigger potent innate immunity. However, the therapeutic efficacy of conventional STING agonists, such as 2',3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), is severely… read more here.
Keywords: activation improved; enhanced sting; improved tumor; sting activation ... See more keywords
Nanodrug Augmenting Antitumor Immunity for Enhanced TNBC Therapy via Pyroptosis and cGAS-STING Activation.
Sign Up to like & getrecommendations! Published in 2023 at "Nano letters"
DOI: 10.1021/acs.nanolett.3c01008
Abstract: Pyroptosis is a proinflammatory form of programmed cell death that results in the release of cellular contents and activation of immune responses. However, GSDME (a pyroptosis-executed protein) is suppressed in many cancers. Herein, we constructed… read more here.
Keywords: via pyroptosis; nanodrug augmenting; pyroptosis; augmenting antitumor ... See more keywords
Oxidation-Responsive PolyMOF Nanoparticles for Combination Photodynamic-Immunotherapy with Enhanced STING Activation.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01333
Abstract: Stimulator of interferon genes (STING) activation by STING agonists has been recognized as one of the potent and promising immunotherapy strategies. However, the immunosuppressive tumor microenvironment always hinders the therapeutic efficacy of cancer immunotherapy. In… read more here.
Keywords: immunotherapy; enhanced sting; combination photodynamic; sting activation ... See more keywords
Lanthanide-Nucleotide Coordination Nanoparticles for STING Activation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03266
Abstract: Activation of the stimulator of interferon genes (STING) is essential for blocking viral infections and eliciting antitumor immune responses. Local injection of synthetic STING agonists, such as 2'3'-cGAMP [cGAMP = cyclic 5'-guanosine monophosphate (cGMP)-adenosine monophosphate… read more here.
Keywords: activation; nanoparticles sting; lanthanide nucleotide; nucleotide coordination ... See more keywords
Manganese Oxide-Incorporated Hybrid Lipid Nanoparticles Amplify the Potency of mRNA Vaccine via Oxygen Generation and STING Activation.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c12166
Abstract: Messenger RNA (mRNA) vaccines have exhibited enormous potential in the treatment of human diseases; however, their widespread applications are curtailed by the induction of reactive oxygen species during mRNA translation, which greatly compromises the translation… read more here.
Keywords: mrna translation; oxygen; mrna vaccine; sting activation ... See more keywords
DNA2 protein destruction dictates DNA hyperexcision, cGAS–STING activation, and innate immune response in CDK12-deregulated cancers
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2413732122
Abstract: Significance The protein kinase gene CDK12 is frequently altered genetically in human cancers including prostate, ovarian, and breast cancer. Loss of CDK12 has been linked to enhanced anticancer immunity in prostate cancer. Here, we report… read more here.
Keywords: dna2 protein; cdk12; immune response; response cdk12 ... See more keywords
Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2421258122
Abstract: Significance Understanding the intricate crosstalk between ER stress and the immune system, particularly the induction of proinflammatory cytokines and type-I IFNs, has significant implications for the development of therapeutic strategies targeting infectious and autoimmune diseases.… read more here.
Keywords: induction isr; activation; subtilase cytotoxin; sting activation ... See more keywords
Dysfunctional telomeres through mitostress‐induced cGAS/STING activation to aggravate immune senescence and viral pneumonia
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13594
Abstract: Disproportionately high incidence and mortality of respiratory infection such as influenza A virus (IAV) and SARS‐CoV‐2 have been evidenced in the elderly, but the role and the mechanism of age‐associated immune deregulation in disease exacerbation… read more here.
Keywords: viral pneumonia; senescence; cgas sting; sting activation ... See more keywords
PLAGL1 overexpression induces cytoplasmic DNA accumulation that triggers cGAS/STING activation
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70130
Abstract: Pancreatic β‐cell damage mediated by apoptosis is believed to be a main trigger of type 1 diabetes mellitus (T1DM), which is proposed as an organ‐specific autoimmune disease mediated by T cells. Nonetheless, the fundamental origins… read more here.
Keywords: accumulation triggers; dna accumulation; cytoplasmic dna; sting activation ... See more keywords
STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.ado0082
Abstract: The low success rate of cancer nanomedicines has raised debate on the role of the enhanced permeability and retention (EPR) effect on tumor deposition of nanotherapeutics. Here, we report a bifunctional nanoscale coordination polymer (NCP),… read more here.
Keywords: deposition; activation; sting activation; tumor ... See more keywords