In Situ Formed ROS-responsive Hydrogel with STING Agonist and Gemcitabine to Intensify immunotherapy Against Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1002/adhm.202203264
Abstract: Immunotherapy, the most revolutionary anticancer strategy, faces major obstacles in yielding desirable outcomes in pancreatic ductal adenocarcinoma (PDAC) due to the highly immunosuppressive tumor microenvironment (TME). Meanwhile, when used alone, the traditional first-line chemotherapeutic agent… read more here.
Keywords: sting agonist; immunotherapy; hydrogel; ductal adenocarcinoma ... See more keywords
Combination of a STING Agonist and Photothermal Therapy Using Chitosan Hydrogels for Cancer Immunotherapy.
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DOI: 10.1021/acs.biomac.3c00196
Abstract: Cyclic dinucleotides (CDNs) are a promising class of immune agonists that trigger the stimulator of interferon genes (STING) to activate both innate and acquired immunity. However, the efficacy of CDNs is limited by drug delivery… read more here.
Keywords: immunotherapy; sting agonist; photothermal therapy; combination sting ... See more keywords
STING Agonist-Derived LNP-mRNA Vaccine Enhances Protective Immunity Against SARS-CoV-2
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DOI: 10.1021/acs.nanolett.2c04883
Abstract: Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines has provided large-scale immune protection to the public. To elicit a robust immune response against SARS-CoV-2 infections, antigens produced by mRNAs encoding SARS-CoV-2 Spike glycoprotein… read more here.
Keywords: sting agonist; derived lnp; agonist derived; lnp mrna ... See more keywords
Discovery of a photoactivatable dimerized STING agonist based on the benzo[b]selenophene scaffold
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DOI: 10.1039/d2sc06860e
Abstract: Stimulator of interferon genes (STING) agonism presents a powerful weapon for cancer immunotherapy. This study reports a novel dimerized STING agonist diBSP01, which exhibited promising STING binding and activation properties in vitro, based on the… read more here.
Keywords: sting agonist; dimerized sting; benzo selenophene; based benzo ... See more keywords
Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I+ tumors
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2200568119
Abstract: Significance Immunotherapy provides long-term remissions in numerous types of cancer but is ineffective in most tumors with poor immune cell infiltrates or lacking T cell epitopes or MHC I molecules. Agents that activate the STING… read more here.
Keywords: synergy sting; sting agonist; immunotherapy; deficient mhc ... See more keywords
Tumor-targeted delivery of a STING agonist improves cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214278119
Abstract: Significance The cGAS-STING pathway plays a key role in antitumor immunity. Several STING agonists have shown antitumor efficacy in preclinical studies and are under clinical development. However, systemic administration of STING agonists may have adverse… read more here.
Keywords: sting agonist; tumor targeted; agonist improves; delivery sting ... See more keywords
STING agonist enhances the efficacy of programmed death-ligand 1 monoclonal antibody in breast cancer immunotherapy by activating the interferon-β signalling pathway
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DOI: 10.1080/15384101.2022.2029996
Abstract: ABSTRACT This study aimed to explore the role of a stimulator of interferon (IFN) gene (STING) agonist in breast cancer (BCa) immunotherapy. Clinical samples were collected from 37 patients with BCa. A tumor-bearing mouse model… read more here.
Keywords: sting agonist; death; breast cancer; mice ... See more keywords
602 STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment
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DOI: 10.1136/jitc-2020-sitc2020.0602
Abstract: Background The degree of immune infiltration in tumors, especially CD8+ T cells, greatly impacts patient disease course and response to interventional immunotherapy. Hence, enhancement of TIL prevalence is a preferred clinical endpoint, one that may… read more here.
Keywords: sting agonist; melanoma; tls; formation ... See more keywords
Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
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DOI: 10.1158/1078-0432.ccr-21-1914
Abstract: Purpose: Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients and Methods: A small-molecule STING agonist, IACS-8779, was stereotactically administered using… read more here.
Keywords: results clinical; sting agonist; intratumoral delivery; delivery sting ... See more keywords
Abstract 2838: Peritoneal immune evasion can be overcome with STING agonist treatment in peritoneal carcinomatosis of colon cancer
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DOI: 10.1158/1538-7445.am2020-2838
Abstract: Introduction: Peritoneal immune system plays an important role during the peritoneal dissemination of colon cancers. Therefore, tumor-induced T cell anergy in peritoneal cavity could lead to immune evasion and the progression of peritoneal carcinomatosis. Here,… read more here.
Keywords: cancer; colon cancer; peritoneal carcinomatosis; sting agonist ... See more keywords
Abstract 1804: Durable eradication of tumors by single injections of a pHLIP-STING agonist
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DOI: 10.1158/1538-7445.am2023-1804
Abstract: Purpose: pHLIPs (pH-Low Insertion Peptides) target cell surface acidity resulting from the metabolism of cells in a solid tumor. The acidity causes pHLIPs to insert as transmembrane helices, and attached cargoes can be delivered into… read more here.
Keywords: eradication tumors; sting agonist; durable eradication; tumors single ... See more keywords